Evidence map›Paper›PMID 28610948›Full record

ReviewTrends in neurosciences2017

Adaptive Capacity: An Evolutionary Neuroscience Model Linking Exercise, Cognition, and Brain Health.

David A Raichlen, Gene E Alexander

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in neurosciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 6 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 6 syntheses or guidelines pooled it, 224 citations in OpenAlex.

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  11. Nutritional supplementation boosts aerobic exercise effects on functional brain systems.Journal of applied physiology (Bethesda, Md. : 1985) · 2019
    Trial
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

David A RaichlenSchool of Anthropology, University of Arizona, 1009 East South Campus Drive, Tucson AZ 85721, USA. Electronic address: raichlen@email.arizona.edu.
Gene E AlexanderDepartments of Psychology and Psychiatry, Neuroscience and Physiological Sciences Graduate Interdisciplinary Programs, and BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ 85721, USA; Arizona Alzheimer's Consortium, Phoenix, AZ 85006, USA.
Arizona Alzheimer’s ConsortiumUniversity of Arizona · US

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI GONZALEZ HERNANDEZ, GRACIELA · 2001 to 2020
$32.5M
Epigenetic, Neuroimaging & Behavioral Effects of Hypertension in the Aging BrainR01AG049464 · NIA · UNIVERSITY OF ARIZONA · PI ALEXANDER, GENE E, BARNES, CAROL A. · 2014 to 2018
$2.4M
NIA NIH HHS P30 AG019610NIA NIH HHS R01 AG049464
6 · The paper itself

Abstract

The field of cognitive neuroscience was transformed by the discovery that exercise induces neurogenesis in the adult brain, with the potential to improve brain health and stave off the effects of neurodegenerative disease. However, the basic mechanisms underlying exercise-brain connections are not well understood. We use an evolutionary neuroscience approach to develop the adaptive capacity model (ACM), detailing how and why physical activity improves brain function based on an energy-minimizing strategy. Building on studies showing a combined benefit of exercise and cognitive challenge to enhance neuroplasticity, our ACM addresses two fundamental questions: (i) what are the proximate and ultimate mechanisms underlying age-related brain atrophy, and (ii) how do lifestyle changes influence the trajectory of healthy and pathological aging?

Indexed as

Models, NeurologicalAgingAnimalsBiological EvolutionBrainCognitionExerciseHumansNeuroprotection

Identifiers

PMID28610948
PMCPMC5926798
OpenAlexW2624144577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.