Evidence map›Paper›PMID 28610943›Full record

ReviewSeminars in cell & developmental biology2017

Stretch-induced actomyosin contraction in epithelial tubes: Mechanotransduction pathways for tubular homeostasis.

Kriti Sethi, Erin J Cram, Ronen Zaidel-Bar

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kriti SethiMechanobiology Institute, National University of Singapore, T-Lab #05-01, 5A Engineering Drive 1, 117411, Singapore.
Erin J CramNortheastern University, Department of Biology, 360 Huntington Avenue, 134 Mugar Hall, Boston, MA 02115, United States of America. Electronic address: E.Cram@northeastern.edu.
Ronen Zaidel-BarMechanobiology Institute, National University of Singapore, T-Lab #05-01, 5A Engineering Drive 1, 117411, Singapore; Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: mbizbr@nus.edu.sg.

Funding

In vivo analysis of mechanotransductionR01GM110268 · NIGMS · NORTHEASTERN UNIVERSITY · PI CRAM, ERIN JEAN · 2014 to 2023
$2.8M
NIGMS NIH HHS R01 GM110268
6 · The paper itself

Abstract

Many tissues in our body have a tubular shape and are constantly exposed to various stresses. Luminal pressure imposes tension on the epithelial and myoepithelial or smooth muscle cells surrounding the lumen of the tubes. Contractile forces generated by actomyosin assemblies within these cells oppose the luminal pressure and must be calibrated to maintain tube diameter homeostasis and tissue integrity. In this review, we discuss mechanotransduction pathways that can lead from sensation of cell stretch to activation of actomyosin contractility, providing rapid mechanochemical feedback for proper tubular tissue function.

Indexed as

HomeostasisActomyosinAnimalsBiomechanical PhenomenaEpithelial CellsHumansIntegrinsSignal TransductionActomyosinIntegrinsCalciumContractilityEpithelial tubesIntegrin signalingMechanotransductionRhoASmooth muscleStretch

Identifiers

PMID28610943
PMCPMC5659885

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.