ArticleThe Annals of thoracic surgery2017
Three-Dimensional-Printed Bioengineered Tracheal Grafts: Preclinical Results and Potential for Human Use.
Article in The Annals of thoracic surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Decellularized Rat Lung Extracellular Matrix as an In Vitro Platform for Canine Yolk Sac-Derived Endothelial Precursor Cells for Pulmonary Endothelium Reconstruction Studies.Bioengineering (Basel, Switzerland) · 2026Article
- 3D printing as an innovative tool in personalized management of complex airway diseases: a literature review.Journal of thoracic disease · 2026Review
- Bio-Printed PCL Tracheal Graft in a Large Animal Model: Reproducible Short-Segment Regeneration and Preliminary Upgraded Long-Segment Reconstruction.Bioengineering (Basel, Switzerland) · 2026Article
- Towards a bioengineered airway: advances in tracheal tissue engineering and biofabrication.Frontiers in cell and developmental biology · 2026Review
- Establishment and evaluation of an animal model of acquired tracheomalacia following tracheostomy in rabbits.Pediatric surgery international · 2025Article
- Organic and Synthetic Substitutes in Tracheal Reconstruction: A Scoping Review (2015-2025).Bioengineering (Basel, Switzerland) · 2025Review
- Chondrogenesis in primitive tracheal neocartilage: insights from 3D-printed silicone grafts in a large-scale animal model.American journal of translational research · 2025Article
- Tissue-engineered tracheal implants: Advancements, challenges, and clinical considerations.Bioengineering & translational medicine · 2024Review
- Identifying Molecular Pathophysiology and Potential Therapeutic Options in Iatrogenic Tracheal Stenosis.Biomedicines · 2024Article
- Validation of airway porcine epithelial cells as an alternative to human in vitro preclinical studies.Scientific reports · 2023Article
- Article
- Current Status and Future Outlook of Additive Manufacturing Technologies for the Reconstruction of the Trachea.Journal of functional biomaterials · 2023Review
- Biomaterials-based additive manufacturing for customized bioengineering in management of otolaryngology: a comprehensive review.Frontiers in bioengineering and biotechnology · 2023Review
- Development of tissue-engineered tracheal scaffold with refined mechanical properties and vascularisation for tracheal regeneration.Frontiers in bioengineering and biotechnology · 2023Article
- The Growing Medical Need for Tracheal Replacement: Reconstructive Strategies Should Overcome Their Limits.Frontiers in bioengineering and biotechnology · 2022Review
- Development and clinical translation of tubular constructs for tracheal tissue engineering: a review.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Article
- Motility Improvement of Biomimetic Trachea Scaffold via Hybrid 3D-Bioprinting Technology.Polymers · 2021Article
- Novel composite trachea grafts using 3-dimensional printing.JTCVS open · 2021Article
- Tissue engineering applications in otolaryngology-The state of translation.Laryngoscope investigative otolaryngology · 2020Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to develop a process using three-dimensional (3D) printing to create bioengineered tracheal grafts (BETGs) for reconstruction of anterior tracheal defects in a large-animal model (porcine) that would have translational relevance for potential human use.
methodsPreoperative computed tomographic scans were used to create virtual 3D models of the animal airways. Anatomically scaled tracheal grafts were subsequently developed using 3D-printed polycaprolactone and extracellular matrix. A 4-cm anterior tracheal defect (about 50% of the length of the subject trachea) was surgically created in 4-week-old female Yorkshire pigs and reconstructed using the customized grafts. Gross and microscopic analyses of the grafts were performed.
resultsThe BETGs were implanted in 7 animals. There was adequate graft-native trachea size match at the operation. The trachea was successfully reconstructed in all cases. Gross examination at autopsy showed a structurally intact, well-incorporated graft. Histologic evaluation showed respiratory mucosal coverage and vascularity of the graft. Five of 7 animals outlived the 3-month study period. The animals had approximately 100% growth during the study period.
conclusionsWe report of a 3D-printed BETG to repair long-segment anterior tracheal defects in a large-animal model. Although the study duration is short, this work presents an efficient strategy for tracheal graft bioengineering with potential translational relevance for human use.
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