ArticleNeurotoxicology2018
Prenatal manganese exposure and intrinsic functional connectivity of emotional brain areas in children.
Article in Neurotoxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Toxicant exposure and the developing brain: A systematic review of the structural and functional MRI literature.Neuroscience and biobehavioral reviews · 2023Pooled it
- Heavy metals and neurodevelopment of children in low and middle-income countries: A systematic review.PloS one · 2022Pooled it
- Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis.Environmental health : a global access science source · 2020Pooled it
- Sexual dimorphism in the programming effects of prenatal manganese multi-media biomarker on temporal cognition in school-aged children.Scientific reports · 2026Article
- Children's exposure to chemical contaminants: Demographic disparities and associations with the developing basal ganglia.Environmental research · 2024Article
- An Industry-Relevant Metal Mixture, Iron Status, and Reported Attention-Related Behaviors in Italian Adolescents.Environmental health perspectives · 2024Article
- Prenatal manganese biomarkers and operant test battery performance in Mexican children: Effect modification by child sex.Environmental research · 2023Article
- Sex-specific association between prenatal manganese exposure and working memory in school-aged children in Mexico city: An exploratory multi-media approach.Environmental pollution (Barking, Essex : 1987) · 2023Article
- Early-Life Critical Windows of Susceptibility to Manganese Exposure and Sex-Specific Changes in Brain Connectivity in Late Adolescence.Biological psychiatry global open science · 2023Article
- Environmental Toxicants and the Developing Brain.Biological psychiatry · 2023Review
- Associations between Elemental Metabolic Dynamics and Default Mode Network Functional Connectivity Are Altered in Autism.Journal of clinical medicine · 2023Article
- Environmental chemical exposures and mental health outcomes in children: a narrative review of recent literature.Frontiers in toxicology · 2023Review
- Topological network properties of resting-state functional connectivity patterns are associated with metal mixture exposure in adolescents.Frontiers in neuroscience · 2023Article
- Neuro-environmental interactions: a time sensitive matter.Frontiers in computational neuroscience · 2023Article
- Association between Long-Term Air Pollution, Chronic Traffic Noise, and Resting-State Functional Connectivity in the 1000BRAINS Study.Environmental health perspectives · 2022Article
- Sex-specific effects of prenatal undernutrition on resting-state functional connectivity in the human brain at age 68.Neurobiology of aging · 2022Article
- Prenatal metal mixture concentrations and reward motivation in children.Neurotoxicology · 2022Article
- D-Ribose-L-Cysteine Improves Glutathione Levels, Neuronal and Mitochondrial Ultrastructural Damage, Caspase-3 and GFAP Expressions Following Manganese-Induced Neurotoxicity.Neurotoxicity research · 2021Article
- Critical windows of susceptibility in the association between manganese and neurocognition in Italian adolescents living near ferro-manganese industry.Neurotoxicology · 2021Article
- N-Acetylcysteine Ameliorates Neurotoxic Effects of Manganese Intoxication in Rats: A Biochemical and Behavioral Study.Neurochemical research · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Manganese (Mn) is an essential trace metal that is neurotoxic at high levels of exposure. Disruption of brain maturation processes during the prenatal period may have lasting consequences. During this critical period, the developing human brain is uniquely vulnerable to exposure to environmental toxicants such as Mn, and prenatal Mn exposure has been associated with changes in brain areas involved in emotion processing and regulation. The goal of the present pilot study was to examine whether prenatal Mn exposure is associated with changes in the intrinsic functional connectivity (iFC) of the brain in childhood, focusing on changes in emotional brain areas. We selected 15 subjects (age 6-7 years) from an ongoing longitudinal birth cohort study to participate in a resting state functional magnetic resonance imaging (fMRI) study. Prenatal Mn exposure was determined from maternal blood collected during the 2nd and 3rd trimesters of pregnancy. We used seed-based correlation analyses and independent component analyses to examine whether prenatal Mn exposure was associated with the iFC of the brain in children. We found that the right globus pallidus showed reduced iFC with the dorsal anterior cingulate cortex and lateral prefrontal cortex in children who were exposed to higher prenatal Mn levels, after controlling for sociodemographic confounders (SES, maternal education, child sex, home environment support) and environmental confounders (prenatal lead exposure and air pollution). These findings suggest that prenatal Mn exposure is associated with reduced iFC of brain areas involved in emotion processing and regulation in children. Future studies should investigate whether this reduced iFC mediates the association between prenatal Mn exposure and emotional dysfunction in childhood.
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