ArticleBMC public health2017
Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study.
Article in BMC public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Severe malnutrition or famine exposure in childhood and cardiometabolic non-communicable disease later in life: a systematic review.BMJ global health · 2021Pooled it
- Article
- Transgenerational Epigenetic and Phenotypic Inheritance Across Five Generations in Sheep.International journal of molecular sciences · 2025Article
- Severe maternal undernutrition during pregnancy and its long-term effects on the offspring health, with a focus on kidney health.Pediatric nephrology (Berlin, Germany) · 2025Review
- Unveiling the long-term impact: exploring the link between exposure to the great Chinese famine and health-related quality of life in middle-aged and elderly populations through propensity score matching.BMC public health · 2025Article
- Early-life famine exposure and subsequent risk of chronic disease comorbidity in later adulthood: the role of social activities.Frontiers in nutrition · 2025Article
- The association of famine exposure with healthy lifestyles at different life stages in rural older adults in China.Frontiers in public health · 2025Article
- Early-life famine exposure increases the risk of subsequent physical disability: evidence from a national population-based survey.Frontiers in public health · 2025Article
- Perinatal Famine Exposure and Young-Onset Cancer-Lessons from China Health and Nutrition Survey.Cancers · 2024Article
- Analysis of study Global Burden of Disease in 2021: global, regional, and national burden of nutritional deficiency from 1990 to 2021.Frontiers in nutrition · 2024Article
- Separate and combined effects of famine exposure and menarche age on metabolic syndrome among the elderly: a cross-sectional study in China.BMC women's health · 2023Article
- Article
- The association between undiagnosed diabetes and cognitive function: findings from the China health and retirement longitudinal study.BMC endocrine disorders · 2022Article
- Adolescence exposure to China's great famine period and the association of metabolic syndrome in adulthood: a retrospective study.BMC public health · 2022Article
- Chinese famine exposure in early life and metabolic obesity phenotype in middle age: Results from the China health and retirement longitudinal study.Frontiers in endocrinology · 2022Article
- Association of early-life undernutrition and risk of dyslipidemia in adulthood: a population-based cohort study.BMC public health · 2021Article
- Article
- Associations of long-term exposure to ambient nitrogen dioxide with indicators of diabetes and dyslipidemia in China: A nationwide analysis.Chemosphere · 2021Article
- The Association of Sleep Duration With Vision Impairment in Middle-Aged and Elderly Adults: Evidence From the China Health and Retirement Longitudinal Study.Frontiers in medicine · 2021Article
- Chronic stress and adipose tissue in the anorexic state: endocrine and epigenetic mechanisms.Adipocyte · 2020Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTo explore the associations between the Chinese famine exposure in early life and the dyslipidemia in adulthood.
methodsWe selected 2752 participants from the baseline survey of China Health and Retirement Longitudinal Study (CHARLS) 2011-2012 to evaluate the associations of early life the Chinese famine exposure with risk of dyslipidemia in adulthood. Dyslipidemia was defined as TC (Total Cholesterol): HDL-C (High-Density Lipoprotein Cholesterol) ratio ≥ 5.0 or use cholesterol lowering drugs. Famine exposure cohorts were categorized by birthdates of participants. Binary logistics regression model was used to examine the associations of early-life famine exposure with the risk of dyslipidemia.
resultsThe dyslipidemia prevalence of the non-exposed cohort, fetal stage-, infant stage-, and preschool stage-exposed cohorts in adulthood was 15.7%, 23.1%, 22.0%, and 18.6%, respectively. Early-life exposure to the Chinese famine significantly increased LDL cholesterol concentrations in adulthood after adjusted for age. The risks of dyslipidemia in fetal (OR = 1.58; 95% CI: 1.23-2.03; P < 0.001) and infant (OR = 1.52; 95% CI: 1.15-2.00; P = 0.003) stage-exposed cohorts were significantly higher than the non-exposed cohort after adjusted for gender and current family economic status. Following gender stratification, we found that fetal (OR = 1.80; 95% CI: 1.26-2.57; P = 0.001), infant (OR = 1.75; 95% CI: 1.17-2.62; P = 0.006), and preschool (OR = 1.63; 95% CI: 1.10-2.42; P = 0.015) -stage exposure to severe famine aggravated the risk of dyslipidemia in female adults. However, the similar association was not observed for male adults.
conclusionsEarly-life exposure to severe Chinese famine could link with the higher dyslipidemia risk in female adulthood, but not in male adulthood. This gender-specific effect might be associated with the hypothesis that parents in China prefer boys to girls traditionally or survivors' bias.
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