ArticleBMC cardiovascular disorders2017
The influence of dehydration on the prognosis of acute ischemic stroke for patients treated with tissue plasminogen activator.
Article in BMC cardiovascular disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Hydration Care After Stroke: A Systematic Review of International Clinical Practice Guidelines.Nutrients · 2026Pooled it
- Contribution of dehydration to END in acute ischemic stroke not mediated via coagulation activation.Brain and behavior · 2019Trial
- Association Between Enhanced Hydration Therapy and Improved Prognosis in Patients With Acute Ischemic Stroke Who Were Treated With Thrombolytics: A Preliminary Study.Emergency medicine international · 2025Article
- Association of renal biomarkers with fast progressor phenotype and related outcomes in anterior circulation large vessel occlusion stroke.Frontiers in neurology · 2024Article
- Enteral Nutrition and Hydration in Patients with Acute Stroke: Efficacy of an Automatic Pump System for Water Administration and Flushes-A Pilot Study.Sensors (Basel, Switzerland) · 2022Article
- A New Nomogram for Predicting the Risk of Intracranial Hemorrhage in Acute Ischemic Stroke Patients After Intravenous Thrombolysis.Frontiers in neurology · 2022Article
- Stroke and Athletes: A Scoping Review.International journal of environmental research and public health · 2021Article
- Admission Hydration Status and Ischemic Stroke Outcome-Experience from a National Registry of Hospitalized Stroke Patients.Journal of clinical medicine · 2021Article
- Management of Blood Pressure During and After Recanalization Therapy for Acute Ischemic Stroke.Frontiers in neurology · 2019Review
- Recent advances in the management of transient ischemic attacks.F1000Research · 2017Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany studies have determined that dehydration is an independent predictor of outcome after ischemic stroke (IS); however, none have determined if the use of thrombolytic therapy modifies the negative impact of poor hydration. To inform the stroke registry established at our institution, we conducted a retrospective study to determine if dehydration remains a negative prognostic factor after IS patients treated with tissue plasminogen activator (tPA).
methodsBetween 2007 and 2012, we recruited 382 subjects; 346 had data available and were divided into 2 groups on the basis of their blood urea nitrogen/creatinine (BUN/Cr) ratio. Dehydrated subjects had a BUN/Cr ratio ≥ 15; hydrated subjects had a BUN/Cr < 15. The primary outcome was impairment at discharge as graded by the Barthel Index (BI) and the modified Rankin Scale (mRS).
resultsThe dehydration group had a greater mean age; more women; lower mean levels of hemoglobin, triglycerides, and sodium; and higher mean potassium and glucose levels. A favorable outcome as assessed by the mRS (≤2) was significantly less frequent among dehydrated subjects, but a favorable outcome by the BI (≥60) was not. Logistic regression and multivariate models confirmed that dehydration is an independent predictor of poor outcome by both the mRS and the BI; however, it was not predictive when patients were stratified by Trial of Org 10,172 in Acute Stroke Treatment subtype.
conclusionsOur findings indicate that use of thrombolytic therapy does not eliminate the need to closely monitor hydration status in patients with IS.
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