Evidence map›Paper›PMID 28610471›Full record

ArticleTissue engineering. Part A2018

Mechanically Loading Cell/Hydrogel Constructs with Low-Intensity Pulsed Ultrasound for Bone Repair.

James A Veronick, Fayekah Assanah, Nicole Piscopo, Yasemin Kutes, Varun Vyas, Lakshmi S Nair, Bryan D Huey, Yusuf Khan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Low-Intensity Pulsed Ultrasound Promotes Osteogenesis in Porous Titanium Alloys Through miR-1187/BMP4 Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  4. Article
  5. Active osseointegration in anFrontiers in bioengineering and biotechnology · 2024
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Integration of clinical perspective into biomimetic bioreactor design for orthopedics.Journal of biomedical materials research. Part B, Applied biomaterials · 2022
    Review
  11. Review
  12. Numerical Modeling of Shockwave Treatment of Knee Joint.Materials (Basel, Switzerland) · 2021
    Article
  13. Review
  14. Bone fracture healing: perspectives according to molecular basis.Journal of bone and mineral metabolism · 2021
    Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

James A Veronick1 Department of Biomedical Engineering, University of Connecticut , Storrs, Connecticut.
Fayekah Assanah1 Department of Biomedical Engineering, University of Connecticut , Storrs, Connecticut.
Nicole Piscopo2 Department of Biomedical Engineering, University of Wisconsin , Madison, Wisconsin.
Yasemin Kutes3 Department of Materials Science and Engineering, University of Connecticut , Storrs, Connecticut.
Varun Vyas3 Department of Materials Science and Engineering, University of Connecticut , Storrs, Connecticut.
Lakshmi S Nair1 Department of Biomedical Engineering, University of Connecticut , Storrs, Connecticut.
Bryan D Huey3 Department of Materials Science and Engineering, University of Connecticut , Storrs, Connecticut.
Yusuf Khan1 Department of Biomedical Engineering, University of Connecticut , Storrs, Connecticut.
University of Connecticut · USUniversity of Wisconsin–Madison · US

Funding

Ultrasound As a Physical Force for Enhanced Scaffold-Based Bone RepairR21AR064432 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KHAN, YUSUF M · 2013 to 2014
$372k
NIAMS NIH HHS R21 AR064432
6 · The paper itself

Abstract

Low-intensity pulsed ultrasound (LIPUS) has been shown to be effective for orthopedic fracture repair and nonunion defects, but the specific mechanism behind its efficacy is still unknown. Previously, we have shown a measurable acoustic radiation force at LIPUS intensities traditionally used for clinical treatment and have applied this force to osteoblastic cells encapsulated in type I collagen hydrogels. Our goal in this study is to provide insight and inform the appropriate design of a cell therapy approach to bone repair in which osteoblasts are embedded in collagen hydrogels, implanted into a bony defect, and then transdermally stimulated using LIPUS-derived acoustic radiation force to enhance bone formation at the earliest time points after bone defect repair. To this end, in this study, we demonstrate the ability to measure local hydrogel deformations in response to LIPUS-induced acoustic radiation force and reveal that hydrogel deformation varies with both LIPUS intensity and hydrogel stiffness. Specifically, hydrogel deformation is positively correlated with LIPUS intensity and this deformation is further increased by reducing the stiffness of the hydrogel. We have also shown that encapsulated osteoblastic cells respond to increases in LIPUS intensity by upregulating both cyclooxygenase 2 and prostaglandin E

Indexed as

AnimalsCell- and Tissue-Based TherapyCell LineCyclooxygenase 2DinoprostoneElastic ModulusFinite Element AnalysisFracture HealingHydrogel, Polyethylene Glycol DimethacrylateMiceOsteoblastsOsteogenesisUltrasonographyCyclooxygenase 2DinoprostoneHydrogel, Polyethylene Glycol Dimethacrylateacoustic radiation forcebonecell therapyhydrogelsLIPUS

Identifiers

PMID28610471
PMCPMC5792249
OpenAlexW2626977220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.