Evidence map›Paper›PMID 28609842›Full record

ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2017

Specifying the molecular pattern of sporadic parathyroid tumorigenesis-The Y282D variant of the GCM2 gene.

Elena Marchiori, Maria Rosa Pelizzo, Monika Herten, Danyelle M Townsend, Domenico Rubello, Isabella Merante Boschin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Elena MarchioriDepartment of Oncological Surgical and Gastroenterological Sciences (DiSCOG), University of Padova, Padova, Italy; Department of Vascular and Endovascular Surgery, University Hospital Münster, Münster, Germany. Electronic address: elena.marchiori@gmail.com.
Maria Rosa PelizzoDepartment of Oncological Surgical and Gastroenterological Sciences (DiSCOG), University of Padova, Padova, Italy.
Monika HertenDepartment of Vascular and Endovascular Surgery, University Hospital Münster, Münster, Germany.
Danyelle M TownsendDepartment of Drug Discovery and Pharmaceutical Sciences, Medical University of South Carolina, USA.
Domenico RubelloDepartment of Nuclear Medicine, Radiology and Clinical Pathology, Medicine, Santa Maria della Misericordia Hospital, Rovigo, Italy.
Isabella Merante BoschinDepartment of Oncological Surgical and Gastroenterological Sciences (DiSCOG), University of Padova, Padova, Italy.
University of Padua · ITMedical University of South Carolina · USOspedale Santa Maria della Misericordia di Rovigo · ITUniversity Hospital Münster · DE

Funding

SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20GM103542 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2012 to 2020
$20.2M
NIGMS NIH HHS P20 GM103542
6 · The paper itself

Abstract

objectiveSporadic carcinoma of the parathyroid glands is a rare malignant neoplasia. The GCM2 gene encodes a transcription factor that is crucial to embryonic parathyroid development. The Y282D variant of GCM2 exhibits increased transcriptional activity, and the presence of this variant is significantly associated with a higher prevalence of primitive hyperparathyroidism. The present study investigated the prevalence of the Y282D variant of the GCM2 gene and its association with clinical parameters in patients with a definitive histological diagnosis of sporadic parathyroid carcinoma (SPC) or atypical adenoma (AA).

Indexed as

Base SequenceCarcinogenesisFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleMiddle AgedNuclear ProteinsParathyroid NeoplasmsPolymorphism, Single NucleotideTranscription FactorsGCM2 protein, humanNuclear ProteinsTranscription Factors

Identifiers

PMID28609842
PMCPMC6361162
OpenAlexW2623201319

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.