Evidence map›Paper›PMID 28609654›Full record

ArticleCancer cell2017

Intertumoral Heterogeneity within Medulloblastoma Subgroups.

Florence M G Cavalli, Marc Remke, Ladislav Rampasek, John Peacock, David J H Shih, Betty Luu, Livia Garzia, Jonathon Torchia, Carolina Nor, A Sorana Morrissy and 85 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 774 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
774citing papers in PubMed, 3 pooled it
61.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

774 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,230 citations in OpenAlex.

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  18. Genome-wide DNA methylation analysis of pediatric medulloblastomas from a Brazilian cohort: an exploratory study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  19. Review
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714 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

95 authors at 20 institutions in 17 countries.

Florence M G CavalliThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Marc RemkeDepartment of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf 40225, Germany; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Department of Pediatric Neuro-Oncogenomics, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Düsseldorf 40225, Germany.
Ladislav RampasekDepartment of Computer Science, University of Toronto, Toronto, ON M5S 2E4, Canada; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
John PeacockThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.
David J H ShihThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.
Betty LuuThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Livia GarziaThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Jonathon TorchiaThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.
Carolina NorThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
A Sorana MorrissyThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Sameer AgnihotriUPCI Brain Tumor Program, University of Pittsburgh, Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
Yuan Yao ThompsonThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.
Claudia M Kuzan-FischerThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Hamza FarooqThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.
Keren IsaevInformatics Program, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
Craig DanielsThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Byung-Kyu ChoDepartment of Neurosurgery, Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 30322, South Korea.
Seung-Ki KimDepartment of Neurosurgery, Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 30322, South Korea.
Kyu-Chang WangDepartment of Neurosurgery, Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 30322, South Korea.
Ji Yeoun LeeDepartment of Neurosurgery, Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 30322, South Korea.
Wieslawa A GrajkowskaDepartment of Pathology, The Children's Memorial Health Institute, University of Warsaw, Warsaw 04-730, Poland.
Marta Perek-PolnikDepartment of Oncology, The Children's Memorial Health Institute, University of Warsaw, Warsaw 04-730, Poland.
Alexandre VasiljevicCentre de Pathologie et Neuropathologie Est, Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron 69677, France; ONCOFLAM - Neuro-Oncologie et Neuro-Inflammation Centre de Recherche en Neurosciences de Lyon, Lyon 69008, France.
Cecile Faure-ConterInstitute of Pediatric Hematology and Oncology, Lyon 69008, France.
Anne JouvetCentre de Pathologie EST, Groupement Hospitalier EST, Université de Lyon, Bron 69677, France.
Caterina GianniniDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Amulya A Nageswara RaoDivision of Pediatric Hematology/Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Kay Ka Wai LiDepartment of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Ho-Keung NgDepartment of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Charles G EberhartDepartments of Pathology, Ophthalmology and Oncology, John Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Ian F PollackDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Ronald L HamiltonDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
G Yancey GillespieDepartment of Surgery, Division of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
James M OlsonClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA; Division of Pediatric Hematology/Oncology, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, WA 98145-5005, USA.
Sarah LearyDivision of Pediatric Hematology/Oncology, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, WA 98145-5005, USA.
William A WeissDepartments of Pediatrics, Neurological Surgery and Neurology, University of California San Francisco, San Francisco, CA 94143-0112, USA.
Boleslaw LachDivision of Anatomical Pathology, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada; Department of Pathology and Laboratory Medicine, Hamilton General Hospital, Hamilton, ON L8L 2X2, Canada.
Lola B ChamblessDepartment of Neurological Surgery, Vanderbilt Medical Center, Nashville, TN 37232, USA.
Reid C ThompsonDepartment of Neurological Surgery, Vanderbilt Medical Center, Nashville, TN 37232, USA.
Michael K CooperDepartment of Neurology, Vanderbilt Medical Center, Nashville, TN 37232, USA.
Rajeev VibhakarDepartment of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA.
Peter Hauser2nd Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary.
Marie-Lise C van VeelenDepartment of Neurosurgery, Erasmus University Medical Center, Rotterdam 3015 CE, the Netherlands.
Johan M KrosDepartment of Pathology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Pim J FrenchDepartment of Neurology, Erasmus University Medical Center, Rotterdam 3015 CE, the Netherlands.
Young Shin RaDepartment of Neurosurgery, University of Ulsan, Asan Medical Center, Seoul 05505, South Korea.
Toshihiro KumabeDepartment of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan.
Enrique López-AguilarDivision of Pediatric Hematology/Oncology, Hospital Pediatría Centro Médico Nacional Century XXI, Mexico City 06720, Mexico.
Karel ZitterbartDepartment of Pediatric Oncology, School of Medicine, Masaryk University, Brno 625 00, Czech Republic.
Jaroslav SterbaDepartment of Pediatric Oncology, School of Medicine, Masaryk University, Brno 625 00, Czech Republic.
Gaetano FinocchiaroDepartment of Neuro-Oncology, Istituto Neurologico Besta, Milan 20133, Italy.
Maura MassiminoFondazione IRCCS Istituto Nazionale Tumori, Milan 20133, Italy.
Erwin G Van MeirDepartment of Hematology & Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
Satoru OsukaDepartment of Hematology & Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
Tomoko ShofudaDivision of Stem Cell Research, Institute for Clinical Research, Osaka National Hospital, Osaka 540-0006, Japan.
Almos KleknerDepartment of Neurosurgery, University of Debrecen, Medical and Health Science Centre, Debrecen 4032, Hungary.
Massimo ZolloDipartimento di Biochimica e Biotecnologie Mediche, University of Naples, Naples 80145, Italy.
Jeffrey R LeonardDivision of Pediatric Neurosurgery, Department of Neurosurgery, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, MO 63110, USA.
Joshua B RubinDepartments of Pediatrics, Anatomy and Neurobiology, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, MO 63110, USA.
Nada JabadoDivision of Hematology/Oncology, Department of Pediatrics, McGill University, Montreal, QC H4A 3J1, Canada.
Steffen AlbrechtDepartment of Pathology, McGill University, Montreal, QC H4A 3J1, Canada; Department of Pathology, Montreal Children's Hospital, Montreal, QC H4A 3J1, Canada.
Jaume MoraDevelopmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona 08950, Spain.
Timothy E Van MeterDepartment of Pediatrics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298-0646, USA.
Shin JungDepartment of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Hwasun-gun 519-763, Chonnam South Korea.
Andrew S MooreLady Cilento Children's Hospital, The University of Queensland, Brisbane QLD 4102, Australia; Oncology Service, Children's Health Queensland Hospital and Health Service, South Brisbane, QLD 4029, Australia.
Andrew R HallahanLady Cilento Children's Hospital, The University of Queensland, Brisbane QLD 4102, Australia; Oncology Service, Children's Health Queensland Hospital and Health Service, South Brisbane, QLD 4029, Australia.
Jennifer A ChanDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N 2T9, Canada.
Daniela P C TirapelliDepartment of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.
Carlos G CarlottiDepartment of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.
Maryam FouladiDivision of Hematology/Oncology, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
José PimentelDivison of Pathology, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon 1649-035, Portugal.
Claudia C FariaDivision of Neurosurgery, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon 1649-035, Portugal.
Ali G SaadDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Luca MassimiDepartment of Pediatric Neurosurgery, Catholic University Medical School, Rome 00198, Italy.
Linda M LiauDepartment of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Helen WheelerKolling Institute of Medical Research, The University of Sydney, Sydney, NSW 2065, Australia.
Hideo NakamuraDepartment of Neurosurgery, Kumamoto University Graduate School of Medical Science, Kumamoto 860-8555, Japan.
Samer K ElbabaaDivision of Pediatric Neurosurgery, Department of Neurosurgery, Saint Louis University School of Medicine, St. Louis, MO, USA.
Mario Perezpeña-DiazcontiDepartment of Pathology, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico.
Fernando Chico Ponce de LeónDepartment of Neurosurgery, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico.
Shenandoah RobinsonDivision of Pediatric Neurosurgery, Rainbow & Babies Children's Hospital, Case Western Reserve, Cleveland, OH 44106, USA.
Michal ZapotockyDivision of Haematology / Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Alvaro LassalettaDivision of Haematology / Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Annie HuangThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Haematology / Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Cynthia E HawkinsThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Pathology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Uri TaboriThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Haematology / Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Eric BouffetThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Haematology / Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Ute BartelsDivision of Haematology / Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Peter B DirksThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
James T RutkaThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Gary D BaderThe Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5G 1L6, Canada; McLaughlin Centre, University of Toronto, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Samuel Lunenfeld Research Institute at Mount Sinai Hospital, University of Toronto, Toronto, ON M5G 1X5, Canada.
Jüri ReimandInformatics Program, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
Anna GoldenbergDepartment of Computer Science, University of Toronto, Toronto, ON M5S 2E4, Canada; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address: anna.goldenberg@utoronto.ca.
Vijay RamaswamyThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Haematology / Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Program in Neuroscience and Mental Health and Division of Neurology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address: vijay.ramaswamy@sickkids.ca.
Michael D TaylorThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address: mdtaylor@sickkids.ca.
Hospital for Sick Children · CASickKids Foundation · CASeoul National University Children's Hospital · KRUniversity of Toronto · CAErasmus MC · NLNeurological Surgery · USUniversity of Pittsburgh · USChinese University of Hong Kong · HKEmory University · USHospital de Santa Maria · PTHospital Infantil de México Federico Gómez · MXMasaryk University · CZSt. Louis Children's Hospital · USUniversidade de São Paulo · BRAsan Medical Center · KRCentro Medico Nacional Siglo XXI · MXChildren's Memorial Health Institute · PLChonnam National University Hwasun Hospital · KRCincinnati Children's Hospital Medical Center · USFondazione IRCCS Istituto Nazionale dei Tumori · IT

Funding

TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3M
Mouse models to discover new drivers of medulloblastomaR01CA159859 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael D. Taylor, WILLIAM A WEISS · 2011 to 2026
$10.4M
Notch signaling in brain tumorsR01NS055089 · NINDS · JOHNS HOPKINS UNIVERSITY · PI EBERHART, CHARLES G · 2007 to 2016
$3.2M
Medulloblastoma and MetastasesR01CA148699 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TAYLOR, MICHAEL D., WEISS, WILLIAM A · 2010 to 2014
$2.4M
CIHRNCI NIH HHS R01 CA148699NCI NIH HHS R01 CA159859NIGMS NIH HHS P41 GM103504NINDS NIH HHS R01 NS055089
6 · The paper itself

Abstract

While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.

Indexed as

Precision MedicineCluster AnalysisCohort StudiesDNA Copy Number VariationsDNA MethylationGene Expression ProfilingGenomicsHumansMedulloblastomacopy numbergene expressionintegrative clusteringmedulloblastomamethylationsubgroups

Identifiers

PMID28609654
PMCPMC6163053
OpenAlexW2626440326

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.