ReviewMolecular oral microbiology2017
Targeted antimicrobial therapy in the microbiome era.
Review in Molecular oral microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Effect of a Short-Term Intervention withInternational journal of environmental research and public health · 2022Trial
- Review
- Structural Equation Modelling as a Proof-of-Concept Tool for Mediation Mechanisms Between Topical Antibiotic Prophylaxis and Six Types of Blood Stream Infection Among ICU Patients.Antibiotics (Basel, Switzerland) · 2024Review
- Three Innovations of Next-Generation Antibiotics: Evolvability, Specificity, and Non-Immunogenicity.Antibiotics (Basel, Switzerland) · 2023Review
- A novel class of antimicrobial drugs selectively targets a Mycobacterium tuberculosis PE-PGRS protein.PLoS biology · 2022Article
- Genome-wide identification of Streptococcus sanguinis fitness genes in human serum and discovery of potential selective drug targets.Molecular microbiology · 2021Article
- The Current Strategies in Controlling Oral Diseases by Herbal and Chemical Materials.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Functional diversity of microbial ecologies estimated from ancient human coprolites and dental calculus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Non-Surgical Periodontal Therapy with Adjunctive Amoxicillin/Metronidazole or Metronidazole When NoAntibiotics (Basel, Switzerland) · 2020Article
- Salivary parameters and oral health status amongst adolescents in Mexico.BMC oral health · 2020Article
- Article
- ePath: an online database towards comprehensive essential gene annotation for prokaryotes.Scientific reports · 2019Article
- A built-in adjuvant-engineered mucosal vaccine against dysbiotic periodontal diseases.Mucosal immunology · 2019Article
- Genomewide Association Study Identifies Cxcl Family Members as Partial Mediators of LPS-Induced Periodontitis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Narrow-Spectrum Antibacterial Agents.MedChemComm · 2018Article
- Targeted antimicrobial therapy in the microbiome era.Molecular oral microbiology · 2017Review
- Specifically targeted antimicrobial peptides: A new and promising avenue in selective antimicrobial therapy.Indian journal of pharmacologyArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Even though the oral microbiome is one of the most complex sites on the body it is an excellent model for narrow-spectrum antimicrobial therapy. Current research indicates that disruption of the microbiome leads to a dysbiotic environment allowing for the overgrowth of pathogenic species and the onset of oral diseases. The gram-negative colonizer, Porphyromonas gingivalis has long been considered a key player in the initiation of periodontitis and Streptococcus mutans has been linked to dental caries. With antibiotic research still on the decline, new strategies are greatly needed to combat infectious diseases. By targeting key pathogens, it may be possible to treat oral infections while allowing for the recolonization of the beneficial, healthy flora. In this review, we examine unique strategies to specifically target periodontal pathogens and address what is needed for the success of these approaches in the microbiome era.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.