SynthesisPloS one2017
Association of asthma with coronary heart disease: A meta analysis of 11 trials.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05589779 (Relationship Between Cardiovascular Disease in Asthma and Eosinophil Subtypes and Biomarkers of Bronchial Remodeling.), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relationship Between Cardiovascular Disease in Asthma and Eosinophil Subtypes and Biomarkers of Bronchial Remodeling.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Asthma increased the risk of atrial fibrillation: insights from clinical association to genetic and molecular evidence.BMC pulmonary medicine · 2026Pooled it
- Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization.Acta dermato-venereologica · 2025Pooled it
- Association Between Asthma and All-Cause Mortality and Cardiovascular Disease Morbidity and Mortality: A Meta-Analysis of Cohort Studies.Frontiers in cardiovascular medicine · 2022Pooled it
- Type 2 inflammation and cardiometabolic disease in middle-aged adults.ERJ open research · 2025Article
- Biomarkers of Oxidative Stress, Systemic Inflammation and Thrombosis in Adult Asthmatic Patients Treated with Inhaled Corticosteroids During Exposure to Fine Particulate Matter.Journal of clinical medicine · 2025Article
- A mode of action protein based approach that characterizes the relationships among most major diseases.Scientific reports · 2025Article
- Lymphocyte-to-high-density lipoprotein ratio and mortality in asthma patients: a novel immunoinflammatory biomarker with nonlinear association.Frontiers in medicine · 2025Article
- Demographic and regional analysis of 22 years of mortality data from coexisting asthma and cardiovascular disease in the United States.Proceedings (Baylor University. Medical Center) · 2025Article
- Review
- Assessment of obstructive airway disease in the multicenter SWORD survey India.Lung India : official organ of Indian Chest Society · 2024Article
- Cardiovascular Events in Patients with Severe Asthma-A Retrospective Study of Two Cohorts: Asthma Type T2 Treated with Biologics and Non-Type T2.Journal of clinical medicine · 2024Article
- Childhood asthma was associated with the presence of cardio-cerebrovascular diseases in US middle-aged and elderly.Preventive medicine reports · 2024Article
- Association between asthma and cardiovascular diseases: A longitudinal follow-up study using a national health screening cohort.The World Allergy Organization journal · 2024Article
- Effect of chronic lung diseases on angina pectoris among Indian adults: longitudinal ageing study in India.Scientific reports · 2024Article
- Factors associated with self-reported diagnosed asthma in urban and rural Malawi: Observations from a population-based study of non-communicable diseases.PLOS global public health · 2024Article
- Sex-Related Differences in the Prevalence of Classical, Non-Classical Risk Factors and Management of the Chronic Coronary Syndrome.Journal of clinical medicine · 2023Article
- Possible Incidental Parkinson's Disease following Asthma: A Nested Case-Control Study in Korea.Journal of personalized medicine · 2023Article
- Mild allergic airways responses to an environmental mixture increase cardiovascular risk in rats.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Correlation between coronary heart disease severity and subsequent chronic rhinosinusitis severity: A retrospective cohort study.International journal of medical sciences · 2023Article
- Increased risk of cataract surgery in patients with allergic disease: a population based cohort study.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWhile the relationship of asthma and coronary heart disease (CHD) (a specific manifestation of cardiovascular disease) has not been described consistently, we tried to defined this relation and explore the influence of gender and asthma status (child- and adult-onset asthma) on this issue.
methodsWe searched published reports that described the relationship of asthma and CHD.
resultsEleven trials were identified, covering 666,355 subjects. Asthma overall was significantly associated with CHD both for prospective trials (HR 1.34 [1.09,1.64], P = 0.005) and for retrospective trials(OR 1.29 [1.13,1.46], P = 0.001), when compared to individuals without asthma. Subgroup analysis split by gender indicated that females with asthma were significantly associated with CHD (HR 1.40 [1.20,1.62], P<0.001), but males with asthma were not significantly related with CHD (HR 1.19 [0.98,1.44], P = 0.07). For the four subgroups (Females with adult-onset asthma,males with adult-onset asthma,females with child-onset asthma,and males with child-onset asthma), pooled analysis of two trials indicated that only females with adult-onset asthma were significantly associated with CHD (HR 2.06 [1.32,3.19], P<0.001).
conclusionsOur data indicated that asthma was associated with CHD, and the relationship between them seemed to derived mostly from females with adult-onset asthma. Considering the limits of our study, these findings should be taken with caution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.