ArticlePloS one2017
Blood biomarkers in male and female participants after an Ironman-distance triathlon.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Trial
- Post-exercise creatine kinase variability: a literature review.Biochemia medica · 2025Review
- Post-race reactions: The emotional paradox of high performance and anxiety - a conventional content analysis.BMC sports science, medicine & rehabilitation · 2024Article
- Transient changes in L-arginine, asymmetric and symmetric dimethyl arginine in triathletes following Norseman Xtreme Triathlon.Frontiers in physiology · 2024Article
- Cardiac function and autonomic cardiac function during a multi-stage cycling event: a brief report.Frontiers in sports and active living · 2024Article
- Impacts of different triathlon races on systemic cytokine profile and metabolic parameters in healthy individuals: a systematic review.BMC sports science, medicine & rehabilitation · 2023Article
- Article
- Kinetics of Cardiac Remodeling and Fibrosis Biomarkers During an Extreme Mountain Ultramarathon.Frontiers in cardiovascular medicine · 2022Article
- Impact of long-lasting moderate-intensity stage cycling event on cardiac function in young female athletes: A case study.PloS one · 2022Article
- Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon.Sports (Basel, Switzerland) · 2021Article
- Transient Reduction of FMD-Response and L-Arginine Accompanied by Increased Levels of E-Selectin, VCAM, and ICAM after Prolonged Strenuous Exercise.Sports (Basel, Switzerland) · 2021Article
- Exercise-induced release of troponin.Clinical cardiology · 2020Review
- Aerobic capacity predict skeletal but not cardiac muscle damage after triathlon - the Iron(WO)man study.Scientific reports · 2020Article
- Biochemical markers after the Norseman Extreme Triathlon.PloS one · 2020Article
- Changes of cardiac biomarkers after ultradistance and standard-distance triathlon.Journal of exercise rehabilitation · 2019Article
- Two-peaked increase of serum myosin heavy chain-α after triathlon suggests heart muscle cell death.BMJ open sport & exercise medicine · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile overall physical activity is clearly associated with a better short-term and long-term health, prolonged strenuous physical activity may result in a rise in acute levels of blood-biomarkers used in clinical practice for diagnosis of various conditions or diseases. In this study, we explored the acute effects of a full Ironman-distance triathlon on biomarkers related to heart-, liver-, kidney- and skeletal muscle damage immediately post-race and after one week's rest. We also examined if sex, age, finishing time and body composition influenced the post-race values of the biomarkers.
methodsA sample of 30 subjects was recruited (50% women) to the study. The subjects were evaluated for body composition and blood samples were taken at three occasions, before the race (T1), immediately after (T2) and one week after the race (T3). Linear regression models were fitted to analyse the independent contribution of sex and finishing time controlled for weight, body fat percentage and age, on the biomarkers at the termination of the race (T2). Linear mixed models were fitted to examine if the biomarkers differed between the sexes over time (T1-T3).
resultsBeing male was a significant predictor of higher post-race (T2) levels of myoglobin, CK, and creatinine levels and body weight was negatively associated with myoglobin. In general, the models were unable to explain the variation of the dependent variables. In the linear mixed models, an interaction between time (T1-T3) and sex was seen for myoglobin and creatinine, in which women had a less pronounced response to the race.
conclusionOverall women appear to tolerate the effects of prolonged strenuous physical activity better than men as illustrated by their lower values of the biomarkers both post-race as well as during recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.