Evidence map›Paper›PMID 28609364›Full record

ArticlePancreas2017

Therapeutic Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients With Acute Recurrent and Chronic Pancreatitis: Data From the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) Study.

David M Troendle, Douglas S Fishman, Bradley A Barth, Matthew J Giefer, Tom K Lin, Quin Y Liu, Maisam Abu-El-Haija, Melena D Bellin, Peter R Durie, Steven D Freedman and 16 more

Registry-linked trialAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pancreas, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03672422 (Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03672422 completednot on this map

Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) CPDPC16-03 Pediatric Longitudinal Cohort Study of Chronic Pancreatitis

Typeobservational_patient_registrySponsorAliye UcRan2017 to 2020Enrolled623ConditionsPancreatitis, Chronic, Pancreatitis, AcuteArmsBlood sample, Patient questionnaires, Saliva sample, Urine sample
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Safety and efficacy of endoscopic retrograde cholangiopancreatography in pediatric pancreatic and biliary disorders.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
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  5. Review
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  11. Observational
  12. Review
  13. Sterility Cultures Following Pancreatectomy with Islet Autotransplantation in the Pediatric Population: Do They Matter?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 6 institutions in 4 countries.

David M TroendleFrom the *Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX; and †Section of Pediatric Gastroenterology and Nutrition, Baylor College of Medicine, Houston, TX; ‡Department of Pediatrics, Seattle Children's Hospital, Seattle, WA; §Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ∥Department of Medicine and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA; ¶Department of Pediatrics, University of Minnesota, University of Minnesota Masonic Children's Hospital, Minneapolis, MN; #Department of Paediatrics, University of Toronto, and Research Institute, The Hospital for Sick Children, Toronto, Canada; **Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA; ††Department of Pediatrics, The Ohio State University and Nationwide Children's Hospital, Columbus, OH; ‡‡Department of Pediatrics, University of California at San Francisco, San Francisco, CA; §§Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; ∥∥Department of Pediatrics, Rady Children's Hospital, San Diego, CA; ¶¶Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada; ##Faculty of Medicine, School of Women's and Children's Health, University of New South Wales and Sydney Children's Hospital Randwick, Sydney, Australia; ***Division of Pediatric Gastroenterology, University of Utah, Salt Lake City, UT; †††Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI; ‡‡‡Department of Pediatric Gastroenterology, Hadassah Hebrew University Hospital, Jerusalem, Israel; and §§§Department of Biostatistics, University of Iowa College of Public Health; and ∥∥∥Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA.
Douglas S Fishman
Bradley A Barth
Matthew J Giefer
Tom K Lin
Quin Y Liu
Maisam Abu-El-Haija
Melena D Bellin
Peter R Durie
Steven D Freedman
Cheryl Gariepy
Tanja Gonska
Melvin B Heyman
Ryan Himes
Sohail Z Husain
Soma Kumar
Mark E Lowe
Veronique D Morinville
Chee Y Ooi
Joseph Palermo
John F Pohl
Sarah Jane Schwarzenberg
Steven Werlin
Michael Wilschanski
M Bridget Zimmerman
Aliye Uc
University of Iowa · USBeth Israel Deaconess Medical Center · USNationwide Children's Hospital · USMontreal Children's Hospital · CASeattle Children's Hospital · USUniversity of Toronto · CA

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
Year 9 Administrative Supplement to INSPPIRE 2U01DK108334 · NIDDK · UNIVERSITY OF IOWA · PI MARK E. LOWE, Aliye Uc · 2015 to 2026
$10.5M
University of Iowa Clinical and Translational Science ProgramUL1TR000442 · NCATS · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2012 to 2013
$10.0M
DYSBIOTIC MICROBIOME IN PANCREATITIS, DIABETES, AND PANCREATIC CANCERU01DK108326 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI FISHER, WILLIAM E · 2015 to 2024
$5.2M
Fatty Acid Defects & Oxidative Stress Modulate Islet Function in Cystic FibrosisR01DK097820 · NIDDK · UNIVERSITY OF IOWA · PI NORRIS, ANDREW W, UC, ALIYE · 2012 to 2016
$1.9M
INSPPIRE TO STUDY ACUTE RECURRENT AND CHRONIC PANCREATITIS IN CHILDRENR21DK096327 · NIDDK · UNIVERSITY OF IOWA · PI UC, ALIYE · 2012 to 2014
$586k
NCATS NIH HHS UL1 TR000442NIDDK NIH HHS P30 DK054759NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK097820NIDDK NIH HHS R21 DK096327NIDDK NIH HHS U01 DK108326NIDDK NIH HHS U01 DK108334
6 · The paper itself

Abstract

objectiveThe aim of this study was to characterize utilization and benefit of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP).

methodsFrom August 2012 to February 2015, 301 children with ARP or CP were enrolled in the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) study. Physicians reported utilization and benefit of therapeutic ERCP at enrollment. Differences were analyzed using appropriate statistical methods.

resultsOne hundred seventeen children (38.9%) underwent at least 1 therapeutic ERCP. The procedure was more commonly performed in children with CP compared with those with ARP (65.8% vs 13.5%, P < 0.0001). Utility of therapeutic ERCP was reported to be similar between ARP and CP (53% vs 56%, P = 0.81) and was found to be helpful for at least 1 indication in both groups (53/99 patients [53.5%]). Predictors for undergoing therapeutic ERCP were presence of obstructive factors in ARP and CP, Hispanic ethnicity, or white race in CP.

conclusionsTherapeutic ERCP is frequently utilized in children with ARP or CP and may offer benefit in selected cases, specifically if ductal obstruction is present. Longitudinal studies are needed to clarify the efficacy of therapeutic ERCP and to explore subgroups that might have increased benefit from such intervention.

Indexed as

Practice Patterns, Physicians'Acute DiseaseAdolescentAge FactorsChildChild, PreschoolCholangiopancreatography, Endoscopic RetrogradeDatabases, FactualFemaleHumansMalePancreatitisPancreatitis, ChronicRecurrenceStentsTime Factors

Identifiers

PMID28609364
PMCPMC5502745
OpenAlexW2626331475

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.