Evidence map›Paper›PMID 28609023›Full record

Observational studyJournal of diabetes2018

Relationships of sex hormone levels with leukocyte telomere length in Black, Hispanic, and Asian/Pacific Islander postmenopausal women.

Yan Song, Michele Cho, Kathleen M Brennan, Brian H Chen, Yiqing Song, JoAnn E Manson, Andrea L Hevener, Nai-Chieh Y You, Anthony W Butch, Simin Liu

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yan SongDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.
Michele ChoDepartment of Gynecology and Obstetrics, University of California, Los Angeles, California, USA.
Kathleen M BrennanDepartment of Gynecology and Obstetrics, University of California, Los Angeles, California, USA.
Brian H ChenDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.
Yiqing SongDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA.
JoAnn E MansonDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Andrea L HevenerDivision of Endocrinology, Diabetes and Hypertension, University of California, Los Angeles, California, USA.
Nai-Chieh Y YouDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.
Anthony W ButchDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Simin LiuDepartment of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island, USA.
University of California, Los Angeles · USFielding Graduate University · USBrigham and Women's Hospital · USBrown University · US

Funding

Mechanisms controlling skeletal muscle mitochondrial function and metabolic healthR01DK109724 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HEVENER, ANDREA L · 2016 to 2020
$2.4M
Telomere and its bio-regulators as predictors for clinical diabetes in womenR21DK084452 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIU, SIMIN · 2009 to 2010
$445k
NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNIDDK NIH HHS R01 DK109724NIDDK NIH HHS R21 DK084452WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

backgroundSex hormones may play important roles in sex-specific biological aging. In the study, we specifically examined associations between circulating sex hormone concentrations and leukocyte telomere length (TL).

methodsA cross-sectional study was conducted among 1124 Black, 444 Hispanic, and 289 Asian/Pacific Islander women in the Women's Health Initiative Observational Cohort. Estradiol and testosterone concentrations were measured using electrochemiluminescence immunoassays; TL was measured using quantitative polymerase chain reaction.

resultsWomen in the study were aged 50-79 years. Estradiol concentrations were not significantly associated with TL in this sample. The associations between total and free testosterone and TL differed by race/ethnicity (P

conclusionsSerum estradiol concentrations were not associated with leukocyte TL in this large sample of postmenopausal women. Total and free testosterone concentrations were inversely associated with TL in Asian/Pacific Islander women, but not in Black and Hispanic women, although future studies to replicate our observations are warranted particularly to address potential ethnicity-specific relationships.

Indexed as

Telomere HomeostasisAsian PeopleBiomarkersBlack or African AmericanCohort StudiesCross-Sectional StudiesEstradiolEthnicityFemaleFollow-Up StudiesHispanic or LatinoHumansLeukocytesMiddle AgedNative Hawaiian or Pacific IslanderPostmenopauseBiomarkersEstradiolSex Hormone-Binding GlobulinTestosteroneagingestradiolsex steroid hormonestelomere lengthtestosterone性类固醇激素睾酮端粒长度老龄化雌二醇

Identifiers

PMID28609023
PMCPMC6499547
OpenAlexW2625007279

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.