ArticleCancer2017
Association between patients' perception of the comorbidity burden and symptoms in outpatients with common solid tumors.
Article in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- High Symptom Burden and Low Functional Status in the Setting of Multimorbidity.Journal of the American Geriatrics Society · 2017 · on this mapTrial
- Real-World Mapping of Multiple Primary Carcinoma Combinations and Survival Outcomes in Shanghai, China: Retrospective Registry-Based Study.JMIR public health and surveillance · 2026Article
- Impact of Hydrocodone Rescheduling on Pharmaceutical Pain Management in End-of-Life Lung Cancer Patients.Journal of palliative care · 2026Article
- Symptom cluster profiles in adolescents with inflammatory bowel disease: Cross-sectional study using ImproveCareNow data.Journal of pediatric gastroenterology and nutrition · 2026Article
- Distinct Symptom Profiles in Younger and Older Patients With Cancer Receiving Chemotherapy.Cancer medicine · 2026Article
- Associations between fear of cancer recurrence and post-traumatic growth in patients with primary liver cancer: a latent profile analysis and mediation analysis.Frontiers in psychiatry · 2026Article
- Disease spectrum and comorbidity patterns of malignant neoplasms: a multi-center hospital-based retrospective analysis of inpatient insurance claims data.Frontiers in oncology · 2026Article
- Time and location of specialty palliative care for women dying with metastatic breast cancer.Breast cancer research and treatment · 2025Article
- Impact of Multimorbidity on Symptom Burden and Symptom Clusters in Patients Receiving Chemotherapy.Cancer medicine · 2025Article
- Predictors of Concordance between Patient-Reported and Provider-Documented Symptoms in the Context of Cancer and Multimorbidity.Applied clinical informatics · 2024Article
- Do presenting symptoms, use of pre-diagnostic endoscopy and risk of emergency cancer diagnosis vary by comorbidity burden and type in patients with colorectal cancer?British journal of cancer · 2022Article
- Symptom burden in transplant ineligible patients with newly diagnosed multiple myeloma: a population-based cohort study.Haematologica · 2021Article
- Symptom burden in patients with common cancers near end-of-life and its associations with clinical characteristics: a real-world study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- A COVID-19 screening tool for oncology telephone triage.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Article
- Comorbid chronic diseases and cancer diagnosis: disease-specific effects and underlying mechanisms.Nature reviews. Clinical oncology · 2019Review
- The Influence of Multiple Chronic Conditions on Symptom Clusters in People With Solid Tumor Cancers.Cancer nursingArticle
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundCancer patients' symptom burden is commonly attributed to their cancer and treatment. Increasingly, cancer patients have many other chronic comorbid conditions. However, the degree to which these comorbid conditions may contribute to the patient-reported symptom burden is unclear.
methodsThis study explored the relations between the presence of comorbid conditions, the symptom experience and burden, and the perceived bother from cancer or comorbid conditions in 3106 cancer patients. The associations between the number of comorbidities (identified from current medications), the patient-reported symptom burden (the number of symptoms scored as ≥7 on the 13-item MD Anderson Symptom Inventory physical scale), the patient-reported bother from comorbid conditions and from cancer (from "not at all" to "extremely"), and the clinician-reported difficulty in caring for patients' symptoms were examined.
resultsAccording to medication lists, 19% of the patients had at least 5 of 12 comorbid conditions. Approximately 39% rated at least 1 symptom as ≥ 7, and this proportion increased with an increasing number of comorbid conditions (48% with ≥ 5 comorbid conditions vs 36% with 1 comorbid condition). One-third of the patients reported moderate or worse bother, and this was significantly associated with an increased number of comorbid conditions (odds ratio [OR], 2.4) and an increased symptom burden (OR, 1.22). Clinician ratings of difficulty in managing patients' symptoms were significantly associated with bother from cancer (OR, 2.0), comorbid conditions (OR, 1.6), and symptom burden (OR, 1.1).
conclusionsComorbidity is common in cancer patients and is associated with a greater symptom burden and clinician reports of difficulty in managing patients' symptoms. Greater attention to comorbid conditions is needed to optimize the symptom management of cancer patients with multimorbidity. Cancer 2017;123:3835-3842. © 2017 American Cancer Society.
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