Evidence map›Paper›PMID 28608728›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2018

Dietary factors and pediatric multiple sclerosis: A case-control study.

Julia Pakpoor, Brandon Seminatore, Jennifer S Graves, Teri Schreiner, Amy T Waldman, Timothy E Lotze, Anita Belman, Benjamin M Greenberg, Bianca Weinstock-Guttman, Gregory Aaen and 21 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. A narrative review of genetic and environmental factors and risk for multiple sclerosis. The design of the Italian multicentric PEDIGREE study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Gut-brain communication in demyelinating disorders.Current opinion in neurobiology · 2020
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 18 institutions in 2 countries.

Julia PakpoorUnit of Health-Care Epidemiology, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Brandon SeminatoreMultiple Sclerosis Center, University of California, San Francisco, San Francisco, CA, USA.
Jennifer S GravesMultiple Sclerosis Center, University of California, San Francisco, San Francisco, CA, USA.
Teri SchreinerDepartment of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.
Amy T WaldmanDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Timothy E LotzeDepartment of Child Neurology, Texas Children's Hospital, Houston, TX, USA.
Anita BelmanDepartment of Neurology, Stony Brook University Medical Center, Stony Brook, NY, USA.
Benjamin M GreenbergDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Bianca Weinstock-GuttmanDepartment of Neurology, State University of New York, Buffalo, NY, USA.
Gregory AaenDepartment of Neurology, Loma Linda University, Loma Linda, CA, USA.
Jan-Mendelt TillemaDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Jamie C McDonaldMultiple Sclerosis Center, University of California, San Francisco, San Francisco, CA, USA.
Janace HartDepartment of Neurology, Regional Pediatric MS Center, University of California, San Francisco, San Francisco, CA, USA.
Jayne M NessDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Yolanda HarrisDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Jennifer RubinDivision of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Meghan CandeeDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Lauren KruppDepartment of Neurology, Stony Brook University Medical Center, Stony Brook, NY, USA.
Mark GormanPartners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital, Boston, MA, USA.
Leslie BensonPartners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital, Boston, MA, USA.
Moses RodriguezDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Tanuja ChitnisDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Soe MarDepartment of Neurology, Washington University in St. Louis, St Louis, MO, USA.
Ilana KahnChildren's National Medical Center, Washington, DC, USA.
John RoseDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Suzan L CarmichaelDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Shelly RoalstadDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Michael WaltzDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
T Charles CasperDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Emmanuelle WaubantMultiple Sclerosis Center, University of California, San Francisco, San Francisco, CA, USA/Department of Neurology, Regional Pediatric MS Center, University of California, San Francisco, San Francisco, CA, USA.
US Network of Pediatric Multiple Sclerosis Centers
University of California, San Francisco · USUniversity of Utah · USMassachusetts General Hospital · USMayo Clinic in Arizona · USStony Brook University Hospital · USUniversity of Alabama at Birmingham · USBrigham and Women's Hospital · USChildren's Hospital of Philadelphia · USChildren's National · USLoma Linda University · USLurie Children's Hospital · USStanford University · USTexas Children's Hospital · USThe University of Texas Southwestern Medical Center · USUniversity at Buffalo, State University of New York · USUniversity of Colorado Denver · USUniversity of Oxford · GBWashington University in St. Louis · US

Funding

ZESTRIL VS. VERAPAMIL IN THE TREATMENT OF HYPERTENSIONM01RR000585 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 1985 to 2006
$30.4M
Institutional Career Development CoreKL2TR002379 · NCATS · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2017 to 2026
$14.9M
Environmental and genetic risk factors for pediatric MSR01NS071463 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WAUBANT, EMMANUELLE LAURENCE · 2010 to 2015
$2.8M
NCATS NIH HHS KL2 TR002379NCRR NIH HHS M01 RR000585NINDS NIH HHS R01 NS071463
6 · The paper itself

Abstract

backgroundThe role of diet in multiple sclerosis (MS) is largely uncharacterized, particularly as it pertains to pediatric-onset disease.

objectiveTo determine the association between dietary factors and MS in children.

methodsPediatric MS patients and controls were recruited from 16 US centers (MS or clinically isolated syndrome onset before age 18, <4 years from symptom onset and at least 2 silent lesions on magnetic resonance imaging). The validated Block Kids Food Screener questionnaire was administered 2011-2016. Chi-squared test compared categorical variables, Kruskal-Wallis test compared continuous variables, and multivariable logistic regression analysis was performed.

resultsIn total, 312 cases and 456 controls were included (mean ages 15.1 and 14.4 years). In unadjusted analyses, there was no difference in intake of fats, proteins, carbohydrates, sugars, fruits, or vegetables. Dietary iron was lower in cases ( p = 0.04), and cases were more likely to consume below recommended guidelines of iron (77.2% of cases vs 62.9% of controls, p < 0.001). In multivariable analysis, iron consumption below recommended guidelines was associated with MS (odds ratio = 1.80, p < 0.01).

conclusionPediatric MS cases may be less likely to consume sufficient iron compared to controls, and this warrants broader study to characterize a temporal relationship. No other significant difference in intake of most dietary factors was found.

Indexed as

DietMultiple SclerosisAdolescentCase-Control StudiesChildDiet SurveysFemaleHumansMaleRisk Factorsall pediatricCase control studiesmultiple sclerosisneurologynutritionalrisk factors in epidemiology

Identifiers

PMID28608728
PMCPMC5711616
OpenAlexW2626592267

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.