ArticleClinical implant dentistry and related research2017
Biophysical regulation of osteotomy healing: An animal study.
Article in Clinical implant dentistry and related research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationship Between Primary/Mechanical and Secondary/Biological Implant Stability.The International journal of oral & maxillofacial implantsPooled it
- Controlled Intramedullary Pressure Fluctuations Enhanced Periosteal and Endosteal Bone Formation in Young, but Not Old, Fischer-344 Rats.Biomimetics (Basel, Switzerland) · 2026Article
- Ossification in Normal and Pathological Contexts: The Key Role of Static Osteogenesis vs. Dynamic Osteogenesis in the Etiopathology of Some Skeletal Alterations.Biomolecules · 2025Review
- Preclinical Performance of a Novel Dental Implant Design Reducing Mechanical Stress in Cortical Bone.Journal of functional biomaterials · 2025Article
- Beyond bone volume: Understanding tissue-level quality in healing of maxillary vs. femoral defects.Acta biomaterialia · 2024Article
- Assessing the Efficacy of Whole-Body Titanium Dental Implant Surface Modifications in Inducing Adhesion, Proliferation, and Osteogenesis in Human Adipose Tissue Stem Cells.Journal of functional biomaterials · 2022Article
- An Osteotomy Tool That Preserves Bone Viability: Evaluation in Preclinical and Clinical Settings.Journal of clinical medicine · 2022Article
- In vivo performance of AlJournal of orthopaedic surgery and research · 2021Article
- Optimizing autologous bone contribution to implant osseointegration.Journal of periodontology · 2020Article
- Radiological implications of crestal and subcrestal implant placement in posterior areas. A cone-beam computed tomography study.Journal of clinical and experimental dentistry · 2020Article
- Comparative Analysis of the Chemical Composition and Microstructure Conformation Between Different Dental Implant Bone Drills.Materials (Basel, Switzerland) · 2019Article
- Understanding Peri-Implantitis as a Plaque-Associated and Site-Specific Entity: On the Local Predisposing Factors.Journal of clinical medicine · 2019Review
- A Novel Osteotomy Preparation Technique to Preserve Implant Site Viability and Enhance Osteogenesis.Journal of clinical medicine · 2019Article
- Effects of a Pasty Bone Cement Containing Brain-Derived Neurotrophic Factor-Functionalized Mesoporous Bioactive Glass Particles on Metaphyseal Healing in a New Murine Osteoporotic Fracture Model.International journal of molecular sciences · 2018Article
- A Review of the Impact of Implant Biomaterials on Osteocytes.Journal of dental research · 2018Review
- A Comparative Assessment of Implant Site Viability in Humans and Rats.Journal of dental research · 2018Article
- Immunomodulatory ECM-like Microspheres for Accelerated Bone Regeneration in Diabetes Mellitus.ACS applied materials & interfaces · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundOsteotomies have been performed for centuries yet there remains a remarkable lack of consensus on optimal methods for cutting bone. There is universal agreement, however, that preserving cell viability is critical. PURPOSE: To identify mechanobiological parameters influencing bone formation after osteotomy site preparation. MATERIALS AND
methodsA murine maxillary osteotomy model was used to evaluate healing. Computational modeling characterized stress and strain distributions in the osteotomy, as well as the magnitude and distribution of heat generated by drilling. The impact of osteocyte death and bone composition were assessed using molecular and cellular assays.
resultsThe phases of osteotomy healing in mice align closely with results in large animals; in addition, molecular analyses extended our understanding of osteoprogenitor cell proliferation, differentiation, and mineralization. Computational analyses provided insights into temperature changes caused by drilling and the mechanobiological state in the healing osteotomies, while concomitant cellular assays correlate drill speed with osteocyte apoptosis and bone resorption. Even when drilling was controlled, trabeculated, spongy (Type III) bone healed faster than densely lamellar (Type I) bone because of the abundance of Wnt responsive osteoprogenitor cells in the former.
conclusionsThese data provide a mechanobiological framework for evaluating tools and technologies designed to improve osteotomy site preparation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.