ArticleEuropean radiology2017
Diffusion-weighted imaging for assessment of synovial inflammation in juvenile idiopathic arthritis: a promising imaging biomarker as an alternative to gadolinium-based contrast agents.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Imaging in Juvenile Idiopathic Arthritis: A Comprehensive Review.The Indian journal of radiology & imaging · 2026Article
- Imaging evaluation of rheumatologic musculoskeletal disorders in children.Skeletal radiology · 2025Review
- Review
- A clinical perspective on imaging in juvenile idiopathic arthritis.Pediatric radiology · 2024Review
- Applications of Diffusion-Weighted MRI to the Musculoskeletal System.Journal of magnetic resonance imaging : JMRI · 2024Review
- Society of skeletal radiology position paper - recommendations for contrast use in musculoskeletal MRI: when is non-contrast imaging enough?Skeletal radiology · 2024Article
- Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee.Seminars in musculoskeletal radiology · 2023Review
- Imaging findings of juvenile idiopathic arthritis and autoinflammatory diseases in children.Japanese journal of radiology · 2023Review
- Fluid-Attenuated Inversion Recovery Sequence with Fat Suppression for Assessment of Ankle Synovitis without Contrast Enhancement: Comparison with Contrast-Enhanced MRI.Diagnostics (Basel, Switzerland) · 2023Article
- Diffusion-weighted MRI of total hip arthroplasty for classification of synovial reactions: A pilot study.Magnetic resonance imaging · 2023Article
- Advances in Musculoskeletal Imaging in Juvenile Idiopathic Arthritis.Biomedicines · 2022Review
- Gadolinium-free assessment of synovitis using diffusion tensor imaging.NMR in biomedicine · 2022Article
- Imaging update in inflammatory arthritis.Journal of clinical orthopaedics and trauma · 2021Article
- What's New for Clinical Whole-body MRI (WB-MRI) in the 21st Century.The British journal of radiology · 2020Review
- Imaging assessment of children presenting with suspected or known juvenile idiopathic arthritis: ESSR-ESPR points to consider.European radiology · 2020Review
- Temporomandibular joint imaging: current clinical applications, biochemical comparison with the intervertebral disc and knee meniscus, and opportunities for advancement.Skeletal radiology · 2020Review
- Evaluation of Periarticular Soft Tissues in Patients With Juvenile Idiopathic Arthritis by Superb Microvascular Imaging and Shear Wave Elastography.Archives of rheumatology · 2020Article
- Keeping up with the progress in the diagnosis and management of pediatric rheumatic diseases.World journal of pediatrics : WJP · 2020Article
- Review
- Imaging of the knee in juvenile idiopathic arthritis.Pediatric radiology · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare dynamic-contrast-enhanced MRI (DCE) and diffusion-weighted imaging (DWI) in quantifying synovial inflammation in juvenile idiopathic arthritis (JIA).
methodsRegions of interest (ROI) were drawn in the synovium of JIA patients on T1 DCE and T2 DWI, followed by extraction of the maximum enhancement (ME), maximum initial slope (MIS), time to peak (TTP), % of different time intensity curve shapes (TIC) and apparent diffusion coefficient (ADC) of the ROIs. Mann-Whitney-U test was used for comparing parameters between MRI-active and -inactive patients (defined by the juvenile arthritis MRI scoring system). Spearman's rank was used to analyse the correlation between DCE and DWI.
resultsThirty-five JIA patients (18 MRI active and 17 MRI inactive) were included. Median age was 13.1 years and 71% were female. ME, MIS, TTP, % TIC 5 and ADC were significantly different in MRI-active versus MRI-inactive JIA with median ADC 1.49 × 10
conclusionsSimilar to DCE parameters, DWI-derived ADC is significantly different in MRI-active JIA as compared to MRI-inactive JIA. The non-invasiveness of DWI combined with its possibility to detect synovial inflammation shows the potential of DWI. KEY POINTS: • MRI can quantify: dynamic contrast-enhanced and diffusion-weighted MRI can quantify synovitis • Both DWI and DCE can differentiate active from inactive JIA • The DWI-derived apparent diffusion coefficient (ADC) is higher in active JIA • DWI is non-invasive and thus safer and more patient-friendly • DWI is a potentially powerful and non-invasive imaging biomarker for JIA.
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