ArticleCurrent opinion in behavioral sciences2015
Behavioral-Cognitive Targets for Cholinergic Enhancement.
Article in Current opinion in behavioral sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed.
- Cognitive Effects of a Cognitive Stimulation Programme on Trained Domains in Older Adults with Subjective Memory Complaints: Randomised Controlled Trial.International journal of environmental research and public health · 2023Trial
- Prenatal choline supplementation improves child sustained attention: A 7-year follow-up of a randomized controlled feeding trial.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Trial
- Choline, a nexus for neurocognitive nutrients: A narrative review.Nutrition research (New York, N.Y.) · 2026Review
- Nauclea officinalis extract rescues working memory deficits in adolescent maternal immune activation offspring by restoring cholinergic signaling.Frontiers in cell and developmental biology · 2026Article
- Contrasting effects of the α7 nicotinic receptor antagonist methyllycaconitine in different rat models of heroin reinstatement.Journal of psychopharmacology (Oxford, England) · 2021Article
- Roles of the Functional Interaction between Brain Cholinergic and Dopaminergic Systems in the Pathogenesis and Treatment of Schizophrenia and Parkinson's Disease.International journal of molecular sciences · 2021Review
- Make a Left Turn: Cortico-Striatal Circuitry Mediating the Attentional Control of Complex Movements.Movement disorders : official journal of the Movement Disorder Society · 2021Review
- Rescuing the attentional performance of rats with cholinergic losses by the M1 positive allosteric modulator TAK-071.Psychopharmacology · 2020Article
- Cholinergic double duty: cue detection and attentional control.Current opinion in psychology · 2019Review
- Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson's disease.Psychopharmacology · 2019Article
- Cholinergic modulation of spatial learning, memory and navigation.The European journal of neuroscience · 2018Review
- Cholinergic genetics of visual attention: Human and mouse choline transporter capacity variants influence distractibility.Journal of physiology, Paris · 2016Review
- Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Cholinergic mechanisms have long been considered a promising target for enhancing cognitive functions. Two distinct yet interacting components of cholinergic activity have been proposed to mediate specific cognitive functions. Transient spikes in cholinergic activity mediate the detection of cues in situations involving attentional mode shifts. More slowly changing cholinergic neuromodulation of cortical circuitry regulates task compliance specifically in response to performance challenges. Increases in cholinergic neuromodulation enhances the generation of cholinergic transients via stimulation of α4β2* nicotinic acetylcholine receptors. Stimulation of these receptors stabilizes attentional performance and increases cue detection rates. Adjunctive treatment with agonists or modulators at these receptors is predicted to benefit unstable attentional performance and low cue detection rates that are common to several brain disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.