ArticleMultiple sclerosis journal - experimental, translational and clinical
Heart rate variability is differentially altered in multiple sclerosis: implications for acute, worsening and progressive disability.
Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Inflammatory Synaptopathy as a Target of Exercise Therapy in the Fight Against Multiple Sclerosis
Study on the Interaction Between Immune, Autonomic and Central Nervous Systems as a Target of Exercise Therapy in Multiple Sclerosis
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Heart rate variability in people with multiple sclerosis: A systematic review and meta-analysis.Acta neurologica Belgica · 2026Pooled it
- Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Comparing two relaxation procedures to ease fatigue in multiple sclerosis: a single-blind randomized controlled trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Trial
- Reduced 24-hour heart rate variability in neurosyphilis: a retrospective case-control study.Frontiers in neurology · 2026Article
- Review
- Review
- Association between Daytime Sleepiness, Fatigue and Autonomic Responses during Head-Up Tilt Test in Multiple Sclerosis Patients.Brain sciences · 2023Article
- Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis.Frontiers in physiology · 2023Article
- Heart rate variability and fatigue in MS: two parallel pathways representing disseminated inflammatory processes?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Review
- Deep Learning Paradigm for Cardiovascular Disease/Stroke Risk Stratification in Parkinson's Disease Affected by COVID-19: A Narrative Review.Diagnostics (Basel, Switzerland) · 2022Review
- Cardiovascular/Stroke Risk Stratification in Parkinson's Disease Patients Using Atherosclerosis Pathway and Artificial Intelligence Paradigm: A Systematic Review.Metabolites · 2022Review
- Cardiac Autonomic Dysfunction in Myasthenia Gravis and Relapsing-Remitting Multiple Sclerosis-A Pilot Study.Journal of clinical medicine · 2021Article
- Evidence of Autonomic Dysfunction in Patients with Relapsing-Remitting Multiple Sclerosis: Heart Rate Variability and Cardiovascular Parameters.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021Article
- Autonomic dysfunctions in multiple sclerosis: Challenges of clinical practice (Review).Experimental and therapeutic medicine · 2020Review
- Cardiac Autonomic Modulation Is Different in Terms of Clinical Variant of Multiple Sclerosis.Journal of clinical medicine · 2020Article
- Evaluation of cardiovascular autonomic dysfunction according to heart rate turbulence and variability in patients with relapsing remitting multiple sclerosisTurkish journal of medical sciences · 2020Article
- Cardiac Autonomic Dysfunction in Multiple Sclerosis: A Systematic Review of Current Knowledge and Impact of Immunotherapies.Journal of clinical medicine · 2020Review
- Relation between Heart Rate Variability and Disease Course in Multiple Sclerosis.Journal of clinical medicine · 2019Article
- Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?Metabolic brain disease · 2019Review
- Heart Rate Variability (HRV) serves as an objective correlate of distress and symptom burden in multiple sclerosis.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSympathovagal imbalance has been associated with poor prognosis in chronic diseases, but there is conflicting evidence in multiple sclerosis.
objectivesThe objective of this study was to investigate the autonomic nervous system dysfunction correlation with inflammation and progression in multiple sclerosis.
methodsHeart rate variability was analysed in 120 multiple sclerosis patients and 60 healthy controls during supine rest and head-up tilt test; the normalised units of low frequency and high frequency power were considered to assess sympathetic and vagal components, respectively. Correlation analyses with clinical and radiological markers of disease activity and progression were performed.
resultsSympathetic dysfunction was closely related to the progression of disability in multiple sclerosis: progressive patients showed altered heart rate variability with respect to healthy controls and relapsing-remitting patients, with higher rest low frequency power and lacking the expected low frequency power increase during the head-up tilt test. In relapsing-remitting patients, disease activity, even subclinical, was associated with lower rest low frequency power, whereas stable relapsing-remitting patients did not differ from healthy controls. Less sympathetic reactivity and higher low frequency power at rest were associated with incomplete recovery from relapse.
conclusionsAutonomic balance appears to be intimately linked with both the inflammatory activity of multiple sclerosis, which is featured by an overall hypoactivity of the sympathetic nervous system, and its compensatory plastic processes, which appear inefficient in case of worsening and progressive multiple sclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.