Evidence map›Paper›PMID 28607726›Full record

ReviewMultiple sclerosis journal - experimental, translational and clinical

Erythrocytes in multiple sclerosis - forgotten contributors to the pathophysiology?

Kira Groen, Vicki E Maltby, Katherine A Sanders, Rodney J Scott, Lotti Tajouri, Jeannette Lechner-Scott

Open access · goldAbstract readReview
In one paragraph

Review in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kira GroenFaculty of Health Sciences and Medicine, Bond University, Australia.
Vicki E MaltbyInformation Based Medicine, Hunter Medical Research Institute, Australia.
Katherine A SandersFaculty of Health Sciences and Medicine, Bond University, Australia.
Rodney J ScottInformation Based Medicine, Hunter Medical Research Institute, Australia.
Lotti TajouriFaculty of Health Sciences and Medicine, Bond University, Australia.
Jeannette Lechner-ScottInformation Based Medicine, Hunter Medical Research Institute, Australia.
Hunter Medical Research Institute · AUBond University · AUJohn Hunter Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is an autoimmune disease characterised by lymphocytic infiltration of the central nervous system and subsequent destruction of myelin and axons. On the background of a genetic predisposition to autoimmunity, environmental triggers are assumed to initiate the disease. The majority of MS research has focused on the pathological involvement of lymphocytes and other immune cells, yet a paucity of attention has been given to erythrocytes, which may play an important role in MS pathology. The following review briefly summarises how erythrocytes may contribute to MS pathology through impaired antioxidant capacity and altered haemorheological features. The effect of disease-modifying therapies on erythrocytes is also reviewed. It may be important to further investigate erythrocytes in MS, as this could broaden the understanding of the pathological mechanisms of the disease, as well as potentially lead to the discovery of novel and innovative targets for future therapies.

Indexed as

antioxidant enzymesErythrocyteshaemorheologymultiple sclerosis

Identifiers

PMID28607726
PMCPMC5433403
OpenAlexW2403913513

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.