ArticleMultiple sclerosis journal - experimental, translational and clinical
Burden of genetic risk variants in multiple sclerosis families in the Netherlands.
Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Contribution of common risk variants to multiple sclerosis in Orkney and Shetland.European journal of human genetics : EJHG · 2021Article
- EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Linkage analysis and whole exome sequencing identify a novel candidate gene in a Dutch multiple sclerosis family.Multiple sclerosis (Houndmills, Basingstoke, England) · 2019Article
- Inferring disease risk genes from sequencing data in multiplex pedigrees through sharing of rare variants.Genetic epidemiology · 2019Article
- Distinct HLA class I and II genotypes and haplotypes are associated with multiple sclerosis in Bahrain.Biomedical reports · 2018Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApproximately 20% of multiple sclerosis patients have a family history of multiple sclerosis. Studies of multiple sclerosis aggregation in families are inconclusive.
objectiveTo investigate the genetic burden based on currently discovered genetic variants for multiple sclerosis risk in patients from Dutch multiple sclerosis multiplex families versus sporadic multiple sclerosis cases, and to study its influence on clinical phenotype and disease prediction.
methodsOur study population consisted of 283 sporadic multiple sclerosis cases, 169 probands from multiplex families and 2028 controls. A weighted genetic risk score based on 102 non-human leukocyte antigen loci and
resultsThe weighted genetic risk score based on all loci was significantly higher in familial than in sporadic cases. The
conclusionFamilial multiple sclerosis patients are more loaded with the common genetic variants than sporadic cases. The difference is mainly driven by
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