ArticleMultiple sclerosis journal - experimental, translational and clinical
Negative prognostic impact of MRI spinal lesions in the early stages of relapsing-remitting multiple sclerosis.
Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Prognostic relevance of MRI in early relapsing multiple sclerosis: ready to guide treatment decision making?Therapeutic advances in neurological disorders · 2024Review
- Prognostic value of spinal cord lesion measures in early relapsing-remitting multiple sclerosis.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Current Updates on the Diagnosis and Management of Multiple Sclerosis for the General Neurologist.Journal of clinical neurology (Seoul, Korea) · 2023Review
- Autologous haematopoietic stem cell transplantation as a first-line disease-modifying therapy in patients with 'aggressive' multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Diagnosis of Progressive Multiple Sclerosis From the Imaging Perspective: A Review.JAMA neurology · 2021Review
- Recurrence and Prognostic Value of Asymptomatic Spinal Cord Lesions in Multiple Sclerosis.Journal of clinical medicine · 2021Article
- Multiple sclerosis lesions in motor tracts from brain to cervical cord: spatial distribution and correlation with disability.Brain : a journal of neurology · 2020Article
- Advances in spinal cord imaging in multiple sclerosis.Therapeutic advances in neurological disorders · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe presence of spinal cord (SC) magnetic resonance imaging (MRI) lesions can be expected to affect the mobility of people with relapsing-remitting MS (pwRRMS), but reports are ambiguous.
objectiveThe objective of this paper is to determine whether the presence of SC MRI lesions in early diagnosed pwRRMS could be considered a predictor of long-term disability.
methodspwRRMS with an SC MRI performed within two years from the onset of symptoms and followed up for at least seven years were included. Patients were grouped into: (a) pwRRMs with at least one SC T2 MRI lesion, and (b) pwRRMs without SC T2 MRI lesions. The primary end point was to evaluate the effects of independent factors on reaching an Expanded Disability Status Score (EDSS) of 4.0.
resultsA total of 239 pwRRMS matched the required criteria: 116 in the group with SC lesions and 123 in the group without SC lesions. At baseline, there were no statistical differences between the two groups. The presence of SC lesions (Exp(b) 4.4, CI 2.1-9.0,
conclusionThe presence of T2 SC MRI lesions detected early from MS onset of RRMS predicts a worse prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.