ReviewMultiple sclerosis journal - experimental, translational and clinical
Myelin oligodendrocyte glycoprotein has a dual role in T cell autoimmunity against central nervous system myelin.
Review in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Callitrichine herpesvirus 3 in the common marmoset is a model of Epstein-Barr virus infection and associated lymphoma.PLoS pathogens · 2026Article
- Proteomics and relationship with axonal pathology in multiple sclerosis: 5-year diffusion tensor imaging study.Brain communications · 2023Article
- Article
- An essential role of virus-infected B cells in the marmoset experimental autoimmune encephalomyelitis model.Multiple sclerosis journal - experimental, translational and clinicalReview
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMyelin oligodendrocyte glycoprotein (MOG) is a candidate primary target of the autoimmune attack on the central nervous system (CNS) in multiple sclerosis (MS). However, the physiological function of MOG has been unclear for a long time.
objectiveWe propose that MOG has a central role in the regulation of tolerance and autoimmunity.
conclusionThe interaction of MOG with DC-SIGN, an innate antigen receptor of myeloid antigen-presenting cells (m-APCs), present inside the CNS (microglia) or in draining lymph nodes (dendritic cells; DCs), keeps these cells in an immature/tolerogenic state. We postulate that this tolerogenic mechanism may be disturbed in MS by unknown factors.
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