Evidence map›Paper›PMID 28607615›Full record

ArticleJournal of arrhythmia2017

Diffuse interstitial fibrosis assessed by cardiac magnetic resonance is associated with dispersion of ventricular repolarization in patients with hypertrophic cardiomyopathy.

David Hurtado-de-Mendoza, Celia P Corona-Villalobos, Iraklis Pozios, Jorge Gonzales, Yalda Soleimanifard, Sanjay Sivalokanathan, Diego Montoya-Cerrillo, Styliani Vakrou, Ihab Kamel, Wilfredo Mormontoy-Laurel and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of arrhythmia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

David Hurtado-de-MendozaHypertrophic Cardiomyopathy Center of Excellence, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 871, Baltimore, MD 21205, USA.
Celia P Corona-VillalobosThe Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, 600 North Wolfe Street, MRI 110B, Baltimore, MD 21287, USA.
Iraklis PoziosHypertrophic Cardiomyopathy Center of Excellence, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 871, Baltimore, MD 21205, USA.
Jorge GonzalesCayetano Heredia University School of Medicine, 430 Honorio Delgado Ave, Lima, LIMA 31, Peru.
Yalda SoleimanifardHypertrophic Cardiomyopathy Center of Excellence, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 871, Baltimore, MD 21205, USA.
Sanjay SivalokanathanHypertrophic Cardiomyopathy Center of Excellence, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 871, Baltimore, MD 21205, USA.
Diego Montoya-CerrilloCayetano Heredia University School of Medicine, 430 Honorio Delgado Ave, Lima, LIMA 31, Peru.
Styliani VakrouHypertrophic Cardiomyopathy Center of Excellence, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 871, Baltimore, MD 21205, USA.
Ihab KamelThe Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, 600 North Wolfe Street, MRI 110B, Baltimore, MD 21287, USA.
Wilfredo Mormontoy-LaurelFaculty of Sciences, Department of Statistics, Demography, Humanities and Social Sciences, Cayetano Heredia University, 430 Honorio Delgado Ave, Lima, LIMA 31, Peru.
Ketty Dolores-CernaFaculty of Sciences, Department of Statistics, Demography, Humanities and Social Sciences, Cayetano Heredia University, 430 Honorio Delgado Ave, Lima, LIMA 31, Peru.
Jacsel SuarezCayetano Heredia University School of Medicine, 430 Honorio Delgado Ave, Lima, LIMA 31, Peru.
Sergio Perez-MeloDepartment of Mathematics and Statistics, Florida International University, S.W. 8th Street, DM 430, Miami, FL 33199, USA.
David A BluemkeDepartment of Radiology and Imaging Sciences, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 10 Center Drive, Rm 10/1C355, Bethesda, MD 20892, USA.
Theodore P AbrahamHypertrophic Cardiomyopathy Center of Excellence, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 871, Baltimore, MD 21205, USA.
Stefan L ZimmermanThe Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, 600 North Wolfe Street, MRI 110B, Baltimore, MD 21287, USA.
M Roselle AbrahamHypertrophic Cardiomyopathy Center of Excellence, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 871, Baltimore, MD 21205, USA.
Johns Hopkins University · USUniversidad Peruana Cayetano Heredia · PEFlorida International University · USNational Institute of Biomedical Imaging and Bioengineering · US

Funding

Molecular Biomedical Imaging Laboratory (NIBIB)ZIAEB000072 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI BLUEMKE, DAVID · 2010 to 2017
$5.0M
6 · The paper itself

Abstract

backgroundHypertrophic cardiomyopathy (HCM) is characterized by myocyte hypertrophy, disarray, fibrosis, and increased risk for ventricular arrhythmias. Increased QT dispersion has been reported in patients with HCM, but the underlying mechanisms have not been completely elucidated. In this study, we examined the relationship between diffuse interstitial fibrosis, replacement fibrosis, QTc dispersion and ventricular arrhythmias in patients with HCM. We hypothesized that fibrosis would slow impulse propagation and increase dispersion of ventricular repolarization, resulting in increased QTc dispersion on surface electrocardiogram (ECG) and ventricular arrhythmias.

methodsECG and cardiac magnetic resonance (CMR) image analyses were performed retrospectively in 112 patients with a clinical diagnosis of HCM. Replacement fibrosis was assessed by measuring late gadolinium (Gd) enhancement (LGE), using a semi-automated threshold technique. Diffuse interstitial fibrosis was assessed by measuring T1 relaxation times after Gd administration, using the Look-Locker sequence. QTc dispersion was measured digitally in the septal/anterior (V1-V4), inferior (II, III, and aVF), and lateral (I, aVL, V5, and V6) lead groups on surface ECG.

resultsAll patients had evidence of asymmetric septal hypertrophy. LGE was evident in 70 (63%) patients; the median T1 relaxation time was 411±38 ms. An inverse correlation was observed between T1 relaxation time and QTc dispersion in leads V1-V4 (

conclusionDiffuse interstitial fibrosis is associated with increased dispersion of ventricular repolarization in leads, reflecting electrical activity in the hypertrophied septum. Interstitial fibrosis combined with ion channel/gap junction remodeling in the septum could lead to inhomogeneity of ventricular refractoriness, resulting in increased QTc dispersion in leads V1-V4.

Indexed as

Corrected QT dispersionHypertrophic cardiomyopathyLate gadolinium enhancementT1 relaxation time

Identifiers

PMID28607615
PMCPMC5459419
OpenAlexW2557000658

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.