ReviewARYA atherosclerosis2016
Review of studies on the fat mass and obesity-associated (FTO) gene interactions with environmental factors affecting on obesity and its impact on lifestyle interventions.
Review in ARYA atherosclerosis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- A complete linkage disequilibrium in a haplotype of three SNPs in Fat Mass and Obesity associated (FTO) gene was strongly associated with anthropometric indices after controlling for calorie intake and physical activity.BMC medical genetics · 2018Trial
- The Effects of Extra Virgin Olive Oil on Alanine Aminotransferase, Aspartate Aminotransferase, and Ultrasonographic Indices of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients Undergoing Low Calorie Diet.Canadian journal of gastroenterology & hepatology · 2018Trial
- A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents.PloS one · 2018Trial
- Association of anthropometric indices with rs9939609Frontiers in nutrition · 2025Article
- Maximal Fat Oxidation During Exercise in Healthy Individuals: Lack of Genetic Association with theGenes · 2024Article
- The future backbone of nutritional science: integrating public health priorities with system-oriented precision nutrition.The British journal of nutrition · 2024Review
- Relation Between Obesity and Type 2 Diabetes: Evolutionary Insights, Perspectives and Controversies.Current obesity reports · 2024Review
- BMI trajectory in adulthood in relation to all-cause and cause-specific mortality: A retrospective cohort study in Taiwan.PloS one · 2023Article
- Unraveling the Complex Interactions between the Fat Mass and Obesity-Associated (FTO) Gene, Lifestyle, and Cancer.Advances in nutrition (Bethesda, Md.) · 2022Review
- Risk variants of obesity associated genes demonstrate BMI raising effect in a large cohort.PloS one · 2022Article
- Overweight and obesity: worldwide risk factors for pediatric hypertension.ARYA atherosclerosis · 2022Article
- Genetic Studies of Metabolic Syndrome in Arab Populations: A Systematic Review and Meta-Analysis.Frontiers in genetics · 2021Review
- Up-regulation of FTO gene expression was associated with increase in skeletal muscle mass in overweight male adolescents.Archives of medical science : AMS · 2019Article
- Paraoxonase 1: The Lectin-Like Oxidized LDL Receptor Type I and Oxidative Stress in the Blood of Men with Type II Obesity.Disease markers · 2019Article
- Effects of gene polymorphisms of metabolic enzymes on the association between red and processed meat consumption and the development of colon cancer; a literature review.Journal of nutritional science · 2018Review
- Plasma stearoyl-CoA desaturase activity indices and bile acid concentrations after a low-fat meal: association with a genetic variant in theDiabetes, metabolic syndrome and obesity : targets and therapy · 2018Article
- Lack of association between glutathione s-transferase mu 1 (Journal of exercise rehabilitation · 2017Article
- Potential of Natural Honey in Controlling Obesity and its Related Complications.Journal of evidence-based integrative medicineReview
- The Role of FTO Genotype in the Association Between FTO Gene Expression and Anthropometric Measures in Obese and Overweight Adolescent Boys.American journal of men's healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of obesity is influenced by environmental and genetic factors. Recently, it has been reported that an interaction between genotype and environmental factors can affect each other's effects on the phenotype. The purpose of this study is to evaluate the recent studies on the fat mass and obesity-associated (FTO) gene interactions with environmental factors affecting on obesity and the impact of these interactions on the success level of the lifestyle intervention.
methodsAll articles published in English from June 1990 to June 2015 were studied.
resultsIn most studies, the role of the FTO risk alleles for obesity is significantly intensified through reduced physical activity and high calorie diet. Furthermore, the results of studies about the effect of FTO on the success level of lifestyle interventions have been contradictory. Some studies show that FTO genotype influences on the success of lifestyle interventions, while other studies did not report it.
conclusionThe results of these studies generally indicate that the effect of the FTO gene on obesity may be influenced by environmental factors and lifestyle. In the other hand, the FTO genotype can affect the success of lifestyle interventions in the prevention and treatment of obesity. Future studies are crucial to elucidate relationships between FTO gene and lifestyle.
Indexed as
Identifiers
28607568PMC5455327W2587328082What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.