ArticleNature communications2017
Reproductive fitness and genetic risk of psychiatric disorders in the general population.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Genetic variants associated with platelet count are predictive of human disease and physiological markers.Communications biology · 2021Pooled it
- Review
- Association of age at first sexual intercourse and lifetime number of sexual partners with cardiovascular diseases: a bi-directional Mendelian randomization study.Frontiers in cardiovascular medicine · 2023Article
- Paternal age and 13 psychiatric disorders in the offspring: a population-based cohort study of 7 million children in Taiwan.Molecular psychiatry · 2022Article
- Article
- A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex.Nature genetics · 2022Article
- Evolution and dysfunction of human cognitive and social traits: A transcriptional regulation perspective.Evolutionary human sciences · 2022Review
- The shared genetic architecture of schizophrenia, bipolar disorder and lifespan.Human genetics · 2021Article
- Genomics at cellular resolution: insights into cognitive disorders and their evolution.Human molecular genetics · 2020Review
- The polygenic architecture of schizophrenia - rethinking pathogenesis and nosology.Nature reviews. Neurology · 2020Review
- The genetic relationship between female reproductive traits and six psychiatric disorders.Scientific reports · 2019Article
- Next-Generation Sequencing Strategies.Cold Spring Harbor perspectives in medicine · 2019Review
- Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders: Findings From the Danish Birth Cohort.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
- Schizophrenia risk and reproductive success: a Mendelian randomization study.Royal Society open science · 2019Article
- Distinguishing genetic correlation from causation across 52 diseases and complex traits.Nature genetics · 2018Article
- Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.Annual review of clinical psychology · 2018Review
- Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits.Genome medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The persistence of common, heritable psychiatric disorders that reduce reproductive fitness is an evolutionary paradox. Here, we investigate the selection pressures on sequence variants that predispose to schizophrenia, autism, bipolar disorder, major depression and attention deficit hyperactivity disorder (ADHD) using genomic data from 150,656 Icelanders, excluding those diagnosed with these psychiatric diseases. Polygenic risk of autism and ADHD is associated with number of children. Higher polygenic risk of autism is associated with fewer children and older age at first child whereas higher polygenic risk of ADHD is associated with having more children. We find no evidence for a selective advantage of a high polygenic risk of schizophrenia or bipolar disorder. Rare copy-number variants conferring moderate to high risk of psychiatric illness are associated with having fewer children and are under stronger negative selection pressure than common sequence variants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.