ArticleScientific reports2017
Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 85 citations in OpenAlex.
- Kidney organoid vascularization: current advancements in the field.Regenerative therapy · 2026Article
- Developmentally inspired synthetic kidney engineering.Nature biotechnology · 2026Review
- Innovative Technologies for Kidney Research: Three-Dimensional Imaging and Quantification.Seminars in nephrology · 2026Review
- Beyond Drainage: How Lymphatic Vessels Instruct Immune Cell Fate.Journal of inflammation research · 2026Review
- Zonal endothelial cell heterogeneity underlies murine renal vascular development.Angiogenesis · 2025Article
- Spatial and Temporal Expression Patterns of EDA2R, PCDH9, and TRAF7 inInternational journal of molecular sciences · 2025Article
- Altered renal vascular patterning reduces ischemic kidney injury and limits age-associated vascular loss.American journal of physiology. Renal physiology · 2025Article
- Kidney organoids: steps towards better organization and function.Biochemical Society transactions · 2024Review
- Enhancing maturity in 3D kidney micro-tissues through clonogenic cell combinations and endothelial integration.Journal of cellular and molecular medicine · 2024Article
- Exploring vasculogenesis in the normal human kidney and clear cell renal cell carcinoma: insights from development to tumor progression and biomarkers for therapy response.Frontiers in oncology · 2024Review
- Vascularization of kidney organoids: different strategies and perspectives.Frontiers in urology · 2024Review
- Netrin 1 directs vascular patterning and maturity in the developing kidney.Development (Cambridge, England) · 2023Article
- Stromal netrin 1 coordinates renal arteriogenesis and mural cell differentiation.Development (Cambridge, England) · 2023Article
- Rho/ROCK activity tunes cell compartment segregation and differentiation in nephron-forming niches.bioRxiv : the preprint server for biology · 2023Article
- Innervation of the developing kidney in vivo and in vitro.Biology open · 2023Article
- Directed differentiation of ureteric bud and collecting duct organoids from human pluripotent stem cells.Nature protocols · 2023Review
- The Beauty and Complexity of Blood Vessel Patterning.Cold Spring Harbor perspectives in medicine · 2022Review
- Vasculogenesis in kidney organoids upon transplantation.NPJ Regenerative medicine · 2022Article
- Production of kidney organoids arranged around single ureteric bud trees, and containing endogenous blood vessels, solely from embryonic stem cells.Scientific reports · 2022Article
- Introducing blood flow in kidney explants by engraftment onto the chick chorioallantoic membrane is not sufficient to induce arterial smooth muscle cell development.Biology open · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The renal vasculature is required for blood filtration, blood pressure regulation, and pH maintenance, as well as other specialised kidney functions. Yet, despite its importance, many aspects of its development are poorly understood. To provide a detailed spatiotemporal analysis of kidney vascularisation, we collected images of embryonic mouse kidneys at various developmental time-points. Here we describe the first stages of kidney vascularisation and demonstrate that polygonal networks of vessels (endothelial plexuses) form in cycles at the periphery of the kidney. We show that kidney vascularisation initiates at E11, when vessels connected to the embryonic circulation form a ring around the ureteric bud. From E13.5, endothelial plexuses organise around populations of cap mesenchymal and ureteric bud cells in a cyclical, predictable manner. Specifically, as the ureteric bud bifurcates, endothelia form across the bifurcation site as the cap mesenchyme splits. The plexuses are vascular, carry erythrocytes, are enclosed within a basement membrane, and can always be traced back to the renal artery. Our results are a major step towards understanding how the global architecture of the renal vasculature is achieved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.