ArticleScientific reports2017
Morphology controls how hippocampal CA1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
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- Effects of transcranial alternating current stimulation on Spike train correlation in two-compartment model neurons.Biological cybernetics · 2025Article
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- Multi-scale modeling to investigate the effects of transcranial magnetic stimulation on morphologically-realistic neuron with depression.Cognitive neurodynamics · 2024Article
- Frequency-domain analysis of membrane polarization in two-compartment model neurons with weak alternating electric fields.Cognitive neurodynamics · 2024Article
- Electric field effects on neuronal input-output relationship by regulating NMDA spikes.Cognitive neurodynamics · 2024Article
- Advanced neuroprosthetic electrode design optimized by electromagnetic finite element simulation: innovations and applications.Frontiers in bioengineering and biotechnology · 2024Review
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- A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics.eLife · 2023Article
- Neuron matters: neuromodulation with electromagnetic stimulation must consider neurons as dynamic identities.Journal of neuroengineering and rehabilitation · 2022Review
- Effects of transcranial alternating current stimulation on spiking activity in computational models of single neocortical neurons.NeuroImage · 2022Article
- Ionic direct current modulation evokes spike-rate adaptation in the vestibular periphery.Scientific reports · 2019Article
- Weak electric fields promote resonance in neuronal spiking activity: Analytical results from two-compartment cell and network models.PLoS computational biology · 2019Article
- Modelling brain-wide neuronal morphology via rooted Cayley trees.Scientific reports · 2018Article
- Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons.Scientific reports · 2018Article
- Collective responses in electrical activities of neurons under field coupling.Scientific reports · 2018Article
- Cortical Network Synchrony Under Applied Electrical FieldFrontiers in neuroscience · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Responses of different neurons to electric field (EF) are highly variable, which depends on intrinsic properties of cell type. Here we use multi-compartmental biophysical models to investigate how morphologic features affect EF-induced responses in hippocampal CA1 pyramidal neurons. We find that the basic morphologies of neuronal elements, including diameter, length, bend, branch, and axon terminals, are all correlated with somatic depolarization through altering the current sources or sinks created by applied field. Varying them alters the EF threshold for triggering action potentials (APs), and then determines cell sensitivity to suprathreshold field. Introducing excitatory postsynaptic potential increases cell excitability and reduces morphology-dependent EF firing threshold. It is also shown that applying identical subthreshold EF results in distinct polarizations on cell membrane with different realistic morphologies. These findings shed light on the crucial role of morphologies in determining field-induced neural response from the point of view of biophysical models. The predictions are conducive to better understanding the variability in modulatory effects of EF stimulation at the cellular level, which could also aid the interpretations of how applied fields activate central nervous system neurons and affect relevant circuits.
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