ArticleScientific reports2017
Selective inhibition of small-diameter axons using infrared light.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 61 citations in OpenAlex.
- How spatial temperature gradients modulate infrared stimulation of the ex vivo rat sciatic nerve.Biophysical journal · 2025Article
- Photobiomodulation for pain relief: Model-based estimates of effective doses of light at the neural target.Journal of photochemistry and photobiology. B, Biology · 2024Article
- Two-photon imaging of excitatory and inhibitory neural response to infrared neural stimulation.Neurophotonics · 2024Article
- Modulation of neuronal dynamics by sustained and activity-dependent continuous-wave near-infrared laser stimulation.Neurophotonics · 2024Article
- Selective neural inhibition via photobiomodulation alleviates behavioral hypersensitivity associated with small sensory fiber activation.Lasers in surgery and medicine · 2024Article
- Combining external physical stimuli and nanostructured materials for upregulating pro-regenerative cellular pathways in peripheral nerve repair.Frontiers in cell and developmental biology · 2024Review
- Nanoparticle-based optical interfaces for retinal neuromodulation: a review.Frontiers in cellular neuroscience · 2024Review
- Selective Infrared Neural Inhibition Can Be Reproduced by Resistive Heating.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Infrared light elicits endothelium-dependent vasodilation in isolated occipital arteries of the rat via soluble guanylyl cyclase-dependent mechanisms.Frontiers in physiology · 2023Article
- A Transmissive Theory of Brain Function: Implications for Health, Disease, and Consciousness.NeuroSci · 2022Article
- Differential immunostaining patterns of transient receptor potential (TRP) ion channels in the rat nodose ganglion.Journal of anatomy · 2022Article
- A review of the bioeffects of low-intensity focused ultrasound and the benefits of a cellular approach.Frontiers in physiology · 2022Review
- Use of an invertebrate animal model (Frontiers in neuroscience · 2022Review
- Single infrared light pulses induce excitatory and inhibitory neuromodulation.Biomedical optics express · 2022Article
- [Study on the temperature characteristics of fast capacitance in patch clamp experiments].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021Article
- Two-photon GCaMP6f imaging of infrared neural stimulation evoked calcium signals in mouse cortical neurons in vivo.Scientific reports · 2021Article
- Optimizing thermal block length during infrared neural inhibition to minimize temperature thresholds.Journal of neural engineering · 2021Article
- Isotonic ion replacement can lower the threshold for selective infrared neural inhibition.Neurophotonics · 2021Article
- Spike frequency-dependent inhibition and excitation of neural activity by high-frequency ultrasound.The Journal of general physiology · 2020Article
- Axonal blockage with microscopic magnetic stimulation.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Novel clinical treatments to target peripheral nerves are being developed which primarily use electrical current. Recently, infrared (IR) light was shown to inhibit peripheral nerves with high spatial and temporal specificity. Here, for the first time, we demonstrate that IR can selectively and reversibly inhibit small-diameter axons at lower radiant exposures than large-diameter axons. We provide a mathematical rationale, and then demonstrate it experimentally in individual axons of identified neurons in the marine mollusk Aplysia californica, and in axons within the vagus nerve of a mammal, the musk shrew Suncus murinus. The ability to selectively, rapidly, and reversibly control small-diameter sensory fibers may have many applications, both for the analysis of physiology, and for treating diseases of the peripheral nervous system, such as chronic nausea, vomiting, pain, and hypertension. Moreover, the mathematical analysis of how IR affects the nerve could apply to other techniques for controlling peripheral nerve signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.