Evidence map›Paper›PMID 28607349›Full record

ArticleScientific reports2017

Knee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study.

Qiang Liu, Jingbo Niu, Hu Li, Yan Ke, Rujun Li, Yuqing Zhang, Jianhao Lin

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05975957 (Photobiomodulation Therapy to Reduce Pain and Inflammation in Patients With Gonarthrosis), which is not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05975957 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Photobiomodulation Therapy to Reduce Pain and Inflammation in Patients With Gonarthrosis: a Multicenter Randomized, Double-blind, Placebo-controlled Clinical Trial

TypeinterventionalSponsorD'Or Institute for Research and EducationRan2023 to 2025Enrolled238ConditionsOsteoarthritis, GonarthrosisArmsPhotomodulation Therapy with the Light-Aid system, Control
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiang LiuPeking University People's Hospital, Arthritis Clinic & Research Center, Beijing, 100044, China.
Jingbo NiuBoston University Clinical Epidemiology Research and Training Unit, the Department of Medicine at Boston Medical Center, Boston, 02118, USA.
Hu LiPeking University People's Hospital, Arthritis Clinic & Research Center, Beijing, 100044, China.
Yan KePeking University People's Hospital, Arthritis Clinic & Research Center, Beijing, 100044, China.
Rujun LiPeking University People's Hospital, Arthritis Clinic & Research Center, Beijing, 100044, China.
Yuqing ZhangBoston University Clinical Epidemiology Research and Training Unit, the Department of Medicine at Boston Medical Center, Boston, 02118, USA.
Jianhao LinPeking University People's Hospital, Arthritis Clinic & Research Center, Beijing, 100044, China. linjianhao@pkuph.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knee symptomatic osteoarthritis (SxOA) was associated with all-cause mortality. Walking disability and NSAIDs use have been postulated as potential mechanisms linking knee SxOA to all-cause mortality. Data were collected on ability of walking for 1 kilometer and use of NSAIDs at baseline and death information at follow-up. Subjects with knee SxOA were identified if at least one knee had both radiographic OA and pain. We first fitted a Cox proportional hazards model to examine the relation of knee SxOA to the risk of all-cause mortality. We then used marginal structural models to decompose total effect of knee SxOA on all-cause mortality into indirect and direct effects via walking disability and use of NSAIDs, respectively. Among 1025 subjects, 99 died over 8 years of follow-up. A multivariable adjusted hazard ratio of mortality for SxOA was 1.98 (95% CI: 1.09-3.62). The indirect effect of knee SxOA on all-cause mortality through either a walking disability or NSAIDs use was 1.92 (95% CI: 0.86-4.26) and 1.45 (95% CI: 0.72-2.92), respectively. The corresponding direct effect was 1.08 (95% CI: 0.55-1.12) and 1.35 (95% CI: 0.75-2.44). In this population-based cohort study, high all-cause mortality from knee SxOA was mediated mainly through a walking disability.

Indexed as

Disability EvaluationWalkingAnti-Inflammatory Agents, Non-SteroidalChinaFemaleHumansMaleMiddle AgedOsteoarthritis, KneeAnti-Inflammatory Agents, Non-Steroidal

Identifiers

PMID28607349
PMCPMC5468322

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.