Evidence map›Paper›PMID 28607172›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Tweety-Homolog 1 Drives Brain Colonization of Gliomas.

Erik Jung, Matthias Osswald, Jonas Blaes, Benedikt Wiestler, Felix Sahm, Torsten Schmenger, Gergely Solecki, Katrin Deumelandt, Felix T Kurz, Ruifan Xie and 12 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 160 citations in OpenAlex.

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  12. Neuro-Cancer Interactions Shape Glioma Intratumoral Heterogeneity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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  14. Innovative Therapeutic Strategies Targeting the Network Architecture of Glioblastoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 3 countries.

Erik JungNeurology Clinic and National Center for Tumor Diseases.ORCID 0000-0002-5016-8202
Matthias OsswaldNeurology Clinic and National Center for Tumor Diseases.
Jonas BlaesClinical Cooperation Unit Neurooncology, German Cancer Consortium.
Benedikt WiestlerDepartment of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar der Technischen Universität München, 81675 Munich, Germany.
Felix SahmClinical Cooperation Unit Neuropathology, German Cancer Consortium.
Torsten SchmengerNeurology Clinic and National Center for Tumor Diseases.
Gergely SoleckiNeurology Clinic and National Center for Tumor Diseases.
Katrin DeumelandtClinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium.
Felix T KurzDepartment of Neuroradiology, and.
Ruifan XieNeurology Clinic and National Center for Tumor Diseases.
Sophie WeilNeurology Clinic and National Center for Tumor Diseases.
Oliver HeilGenomics and Proteomics Core Facility.ORCID 0000-0003-0229-5810
Carina ThoméNeurology Clinic and National Center for Tumor Diseases.
Miriam GömmelNeurology Clinic and National Center for Tumor Diseases.
Mustafa SyedDepartment of Radiation Oncology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Peter HäringDepartment of Medical Physics, and.
Peter E HuberDepartment of Radiation Oncology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Sabine HeilandDepartment of Neuroradiology, and.ORCID 0000-0002-2796-3451
Michael PlattenClinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium.
Andreas von DeimlingClinical Cooperation Unit Neuropathology, German Cancer Consortium.
Wolfgang WickNeurology Clinic and National Center for Tumor Diseases.
Frank WinklerNeurology Clinic and National Center for Tumor Diseases, frank.winkler@med.uni-heidelberg.de.
German Cancer Research Center · DEHeliophysics · USGenomics (United Kingdom) · GBTUM Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early and progressive colonization of the healthy brain is one hallmark of diffuse gliomas, including glioblastomas. We recently discovered ultralong (>10 to hundreds of microns) membrane protrusions [tumor microtubes (TMs)] extended by glioma cells. TMs have been associated with the capacity of glioma cells to effectively invade the brain and proliferate. Moreover, TMs are also used by some tumor cells to interconnect to one large, resistant multicellular network. Here, we performed a correlative gene-expression microarray and

Indexed as

AnimalsBrain NeoplasmsCell Line, TumorCell ProliferationGlioblastomaHumansMaleMembrane ProteinsMiceMice, NudeNeoplasm InvasivenessMembrane ProteinsTTYH1 protein, humanTtyh1 protein, mouseglioblastomagliomainvasionmigrationTtyh1tumor microtubes

Identifiers

PMID28607172
PMCPMC6705725
OpenAlexW2626629374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.