Evidence map›Paper›PMID 28607161›Full record

ArticleJournal of bacteriology2017

Uncharacterized Bacterial Structures Revealed by Electron Cryotomography.

Megan J Dobro, Catherine M Oikonomou, Aidan Piper, John Cohen, Kylie Guo, Taylor Jensen, Jahan Tadayon, Joseph Donermeyer, Yeram Park, Benjamin A Solis and 13 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 59 citations in OpenAlex.

  1. RBMP2 shapes specialized membranes for CObioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Charting the molecular landscape of the cell.Structure (London, England : 1993) · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 10 institutions in 6 countries.

Megan J DobroHampshire College, Amherst, Massachusetts, USA.
Catherine M OikonomouCalifornia Institute of Technology, Pasadena, California, USA.
Aidan PiperHampshire College, Amherst, Massachusetts, USA.
John CohenHampshire College, Amherst, Massachusetts, USA.
Kylie GuoCalifornia Institute of Technology, Pasadena, California, USA.
Taylor JensenCalifornia Institute of Technology, Pasadena, California, USA.
Jahan TadayonCalifornia Institute of Technology, Pasadena, California, USA.
Joseph DonermeyerCalifornia Institute of Technology, Pasadena, California, USA.
Yeram ParkCalifornia Institute of Technology, Pasadena, California, USA.
Benjamin A SolisUniversity at Albany, SUNY, Albany, New York, USA.
Andreas KjærUniversity of Southern Denmark, Odense, Denmark.
Andrew I JewettCalifornia Institute of Technology, Pasadena, California, USA.
Alasdair W McDowallCalifornia Institute of Technology, Pasadena, California, USA.
Songye ChenCalifornia Institute of Technology, Pasadena, California, USA.
Yi-Wei ChangCalifornia Institute of Technology, Pasadena, California, USA.
Jian ShiNational University of Singapore, Singapore, Republic of Singapore.
Poorna SubramanianCalifornia Institute of Technology, Pasadena, California, USA.
Cristina V IancuRosalind Franklin University of Medicine and Science, Chicago, Illinois, USA.
Zhuo LiCity of Hope, Duarte, California, USA.
Ariane BriegelLeiden University, Sylvius Laboratories, Leiden, Netherlands.
Elitza I TochevaUniversity of Montreal, Montreal, Quebec, Canada.
Martin PilhoferETH Zurich, Zurich, Switzerland.
Grant J JensenCalifornia Institute of Technology, Pasadena, California, USA jensen@caltech.edu.ORCID http://orcid.org/0000-0003-1556-4864
California Institute of Technology · USHampshire College · USCity of Hope · USETH Zurich · CHLeiden University · NLNational University of Singapore · SGRosalind Franklin University of Medicine and Science · USUniversité de Montréal · CAUniversity at Albany, State University of New York · USUniversity of Southern Denmark · DK

Funding

Structure and Function of Pathogenesis-Associated Bacterial Structures by Electron CryotomographyR01AI127401 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRANT J JENSEN · 2016 to 2026
$3.9M
NIAID NIH HHS R01 AI127401
6 · The paper itself

Abstract

Electron cryotomography (ECT) can reveal the native structure and arrangement of macromolecular complexes inside intact cells. This technique has greatly advanced our understanding of the ultrastructure of bacterial cells. We now view bacteria as structurally complex assemblies of macromolecular machines rather than as undifferentiated bags of enzymes. To date, our group has applied ECT to nearly 90 different bacterial species, collecting more than 15,000 cryotomograms. In addition to known structures, we have observed, to our knowledge, several uncharacterized features in these tomograms. Some are completely novel structures; others expand the features or species range of known structure types. Here, we present a survey of these uncharacterized bacterial structures in the hopes of accelerating their identification and study, and furthering our understanding of the structural complexity of bacterial cells.

Indexed as

bacteriabacterial ultrastructureelectron cryotomographyelectron microscopyuncharacterized structures

Identifiers

PMID28607161
PMCPMC5553035
OpenAlexW2952748270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.