ArticleThe Journal of biological chemistry2017
Wnt3a induces the expression of acetylcholinesterase during osteoblast differentiation via the Runx2 transcription factor.
Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- The role of DNA methylation on gene expression in the vertebrae of ancestrally benzo[a]pyrene exposed F1 and F3 male medaka.Epigenetics · 2023Article
- Impact of genetic variations in the WNT family members and RUNX2 on dental and skeletal maturation: a cross-sectional study.Head & face medicine · 2023Article
- Functional role of cyanidin-3-O-glucoside in osteogenesis: A pilot study based on RNA-seq analysis.Frontiers in nutrition · 2022Article
- Follicle-stimulating hormone impairs dental pulp stem cells odontogenic differentiation.Journal of cellular and molecular medicine · 2020Article
- Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration.Frontiers in cell and developmental biology · 2020Review
- Angelica polysaccharide promotes proliferation and osteoblast differentiation of mesenchymal stem cells by regulation of long non-coding RNA H19: An animal study.Bone & joint research · 2019Article
- Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells.The Journal of biological chemistry · 2018Article
- Application of donepezil increased collagen 1 expression in mesenchymal stroma cells of an ovine osteoporosis model.Journal of musculoskeletal & neuronal interactions · 2018Article
- Genistein, a Phytoestrogen in Soybean, Induces the Expression of Acetylcholinesterase via G Protein-Coupled Receptor 30 in PC12 Cells.Frontiers in molecular neuroscience · 2018Article
- LncRNA KCNQ1OT1 promotes osteogenic differentiation to relieve osteolysis via Wnt/β-catenin activation.Cell & bioscience · 2018Article
- Enzyme ChE, cholinergic therapy and molecular docking: Significant considerations and future perspectives.International journal of immunopathology and pharmacologyReview
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetylcholinesterase (AChE) hydrolyzes acetylcholine to terminate cholinergic transmission in neurons. Apart from this AChE activity, emerging evidence suggests that AChE could also function in other, non-neuronal cells. For instance, in bone, AChE exists as a proline-rich membrane anchor (PRiMA)-linked globular form in osteoblasts, in which it is proposed to play a noncholinergic role in differentiation. However, this hypothesis is untested. Here, we found that in cultured rat osteoblasts, AChE expression was increased in parallel with osteoblastic differentiation. Because several lines of evidence indicate that AChE activity in osteoblast could be triggered by Wnt/β-catenin signaling, we added recombinant human Wnt3a to cultured osteoblasts and found that this addition induced expression of the
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