ArticleHypertension (Dallas, Tex. : 1979)2017
Mechanisms and Treatment of Halogen Inhalation-Induced Pulmonary and Systemic Injuries in Pregnant Mice.
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Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Inhaled Halogen-Induced Oxidative Renal Damage and Dysfunction: A Lung Heart Kidney Axis.Comprehensive Physiology · 2026Article
- Myocardial SERCA2 Protects Against Cardiac Damage and Dysfunction Caused by Inhaled Bromine.The Journal of pharmacology and experimental therapeutics · 2024Article
- Tadalafil for Treatment of Fetal Growth Restriction: A Review of Experimental and Clinical Studies.Biomedicines · 2024Review
- Lipid biology of plasmalogen-derived halolipids: Signature molecules of myeloperoxidase and eosinophil peroxidase activity.Redox biochemistry and chemistry · 2023Article
- Sex differences in cardiopulmonary effects of acute bromine exposure.Toxicology research · 2021Article
- Halogen-Induced Chemical Injury to the Mammalian Cardiopulmonary Systems.Physiology (Bethesda, Md.) · 2021Review
- Halogen gas exposure: toxic effects on the parturient.Toxicology mechanisms and methods · 2021Article
- Chronic cardiac structural damage, diastolic and systolic dysfunction following acute myocardial injury due to bromine exposure in rats.Archives of toxicology · 2021Article
- Vascular permeability disruption explored in the proteomes of mouse lungs and human microvascular cells following acute bromine exposure.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Organophosphate esters in a cohort of pregnant women: Variability and predictors of exposure.Environmental research · 2020Article
- Vascular Endothelial Growth Factor-121 Administration Mitigates Halogen Inhalation-Induced Pulmonary Injury and Fetal Growth Restriction in Pregnant Mice.Journal of the American Heart Association · 2020Article
- Phosgene inhalation causes hemolysis and acute lung injury.Toxicology letters · 2019Article
- Bromine inhalation mimics ischemia-reperfusion cardiomyocyte injury and calpain activation in rats.American journal of physiology. Heart and circulatory physiology · 2019Article
- Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema.JCI insight · 2018Observational
- Halogen Inhalation-Induced Lung Injury and Acute Respiratory Distress Syndrome.Chinese medical journal · 2018Review
- Bromofatty aldehyde derived from bromine exposure and myeloperoxidase and eosinophil peroxidase modify GSH and protein.Journal of lipid research · 2018Article
- Exposure of neonatal mice to bromine impairs their alveolar development and lung function.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Implication of Oxidative Stress in Fetal Programming of Cardiovascular Disease.Frontiers in physiology · 2018Review
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Authors and funding
13 authors at 2 institutions in 1 country.
James A LambertFrom the Biochemistry, Structural and Stem Cell Biology, Graduate Biomedical Sciences (J.A.L.), Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine (J.A.L., M.A.C., A.L., S.A., S.D., S.M.), Division of Neonatology, Department of Pediatrics (C.R., N.A., T.J.), Division of Cardiovascular Disease, Department of Medicine (W.E.B., L.D.), and Cellular and Molecular Pathology, Department of Pathology (R.P.P.), University of Alabama at Birmingham; and Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University, MO (D.A.F.).
Matthew A CarlisleFrom the Biochemistry, Structural and Stem Cell Biology, Graduate Biomedical Sciences (J.A.L.), Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine (J.A.L., M.A.C., A.L., S.A., S.D., S.M.), Division of Neonatology, Department of Pediatrics (C.R., N.A., T.J.), Division of Cardiovascular Disease, Department of Medicine (W.E.B., L.D.), and Cellular and Molecular Pathology, Department of Pathology (R.P.P.), University of Alabama at Birmingham; and Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University, MO (D.A.F.).
Adam LamFrom the Biochemistry, Structural and Stem Cell Biology, Graduate Biomedical Sciences (J.A.L.), Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine (J.A.L., M.A.C., A.L., S.A., S.D., S.M.), Division of Neonatology, Department of Pediatrics (C.R., N.A., T.J.), Division of Cardiovascular Disease, Department of Medicine (W.E.B., L.D.), and Cellular and Molecular Pathology, Department of Pathology (R.P.P.), University of Alabama at Birmingham; and Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University, MO (D.A.F.).
Saurabh AggarwalFrom the Biochemistry, Structural and Stem Cell Biology, Graduate Biomedical Sciences (J.A.L.), Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine (J.A.L., M.A.C., A.L., S.A., S.D., S.M.), Division of Neonatology, Department of Pediatrics (C.R., N.A., T.J.), Division of Cardiovascular Disease, Department of Medicine (W.E.B., L.D.), and Cellular and Molecular Pathology, Department of Pathology (R.P.P.), University of Alabama at Birmingham; and Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University, MO (D.A.F.).
Stephen DoranFrom the Biochemistry, Structural and Stem Cell Biology, Graduate Biomedical Sciences (J.A.L.), Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine (J.A.L., M.A.C., A.L., S.A., S.D., S.M.), Division of Neonatology, Department of Pediatrics (C.R., N.A., T.J.), Division of Cardiovascular Disease, Department of Medicine (W.E.B., L.D.), and Cellular and Molecular Pathology, Department of Pathology (R.P.P.), University of Alabama at Birmingham; and Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University, MO (D.A.F.).
Changchun RenFrom the Biochemistry, Structural and Stem Cell Biology, Graduate Biomedical Sciences (J.A.L.), Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine (J.A.L., M.A.C., A.L., S.A., S.D., S.M.), Division of Neonatology, Department of Pediatrics (C.R., N.A., T.J.), Division of Cardiovascular Disease, Department of Medicine (W.E.B., L.D.), and Cellular and Molecular Pathology, Department of Pathology (R.P.P.), University of Alabama at Birmingham; and Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University, MO (D.A.F.).
Wayne E BradleyFrom the Biochemistry, Structural and Stem Cell Biology, Graduate Biomedical Sciences (J.A.L.), Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine (J.A.L., M.A.C., A.L., S.A., S.D., S.M.), Division of Neonatology, Department of Pediatrics (C.R., N.A., T.J.), Division of Cardiovascular Disease, Department of Medicine (W.E.B., L.D.), and Cellular and Molecular Pathology, Department of Pathology (R.P.P.), University of Alabama at Birmingham; and Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University, MO (D.A.F.).
Louis Dell'ItaliaFrom the Biochemistry, Structural and Stem Cell Biology, Graduate Biomedical Sciences (J.A.L.), Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine (J.A.L., M.A.C., A.L., S.A., S.D., S.M.), Division of Neonatology, Department of Pediatrics (C.R., N.A., T.J.), Division of Cardiovascular Disease, Department of Medicine (W.E.B., L.D.), and Cellular and Molecular Pathology, Department of Pathology (R.P.P.), University of Alabama at Birmingham; and Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University, MO (D.A.F.).
Namasivayam AmbalavananFrom the Biochemistry, Structural and Stem Cell Biology, Graduate Biomedical Sciences (J.A.L.), Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine (J.A.L., M.A.C., A.L., S.A., S.D., S.M.), Division of Neonatology, Department of Pediatrics (C.R., N.A., T.J.), Division of Cardiovascular Disease, Department of Medicine (W.E.B., L.D.), and Cellular and Molecular Pathology, Department of Pathology (R.P.P.), University of Alabama at Birmingham; and Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University, MO (D.A.F.).
David A FordFrom the Biochemistry, Structural and Stem Cell Biology, Graduate Biomedical Sciences (J.A.L.), Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine (J.A.L., M.A.C., A.L., S.A., S.D., S.M.), Division of Neonatology, Department of Pediatrics (C.R., N.A., T.J.), Division of Cardiovascular Disease, Department of Medicine (W.E.B., L.D.), and Cellular and Molecular Pathology, Department of Pathology (R.P.P.), University of Alabama at Birmingham; and Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University, MO (D.A.F.).
Rakesh P PatelFrom the Biochemistry, Structural and Stem Cell Biology, Graduate Biomedical Sciences (J.A.L.), Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine (J.A.L., M.A.C., A.L., S.A., S.D., S.M.), Division of Neonatology, Department of Pediatrics (C.R., N.A., T.J.), Division of Cardiovascular Disease, Department of Medicine (W.E.B., L.D.), and Cellular and Molecular Pathology, Department of Pathology (R.P.P.), University of Alabama at Birmingham; and Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University, MO (D.A.F.).
Tamas JillingFrom the Biochemistry, Structural and Stem Cell Biology, Graduate Biomedical Sciences (J.A.L.), Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine (J.A.L., M.A.C., A.L., S.A., S.D., S.M.), Division of Neonatology, Department of Pediatrics (C.R., N.A., T.J.), Division of Cardiovascular Disease, Department of Medicine (W.E.B., L.D.), and Cellular and Molecular Pathology, Department of Pathology (R.P.P.), University of Alabama at Birmingham; and Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University, MO (D.A.F.).
Sadis MatalonFrom the Biochemistry, Structural and Stem Cell Biology, Graduate Biomedical Sciences (J.A.L.), Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine (J.A.L., M.A.C., A.L., S.A., S.D., S.M.), Division of Neonatology, Department of Pediatrics (C.R., N.A., T.J.), Division of Cardiovascular Disease, Department of Medicine (W.E.B., L.D.), and Cellular and Molecular Pathology, Department of Pathology (R.P.P.), University of Alabama at Birmingham; and Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University, MO (D.A.F.). sadis@uab.edu.
University of Alabama at Birmingham · USUniversity of Alabama · US
Funding
Nitrite dependent protection against Cl2 gas toxicity_role of chlorinated lipidsU01ES023759 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PATEL, RAKESH P. · 2013 to 2018
$3.9MBromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment StrategiesU01ES026458 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MATALON, SADIS · 2015 to 2019
$3.9MCIALIS® reverses halogen induced injury to pregnant animals and their offspringU01ES027697 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JILLING, TAMAS SANDOR, MATALON, SADIS · 2016 to 2020
$3.7MTraining Program in Cardiovascular PathophysiologyT32HL007918 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BALLINGER, SCOTT W. · 1999 to 2018
$3.6MNHLBI NIH HHS T32 HL007918NIEHS NIH HHS U01 ES023759NIEHS NIH HHS U01 ES026458NIEHS NIH HHS U01 ES027697
Abstract
Inhalation of oxidant gases has been implicated in adverse outcomes in pregnancy, but animal models to address mechanisms and studies to identify potential pregnancy-specific therapies are lacking. Herein, we show that inhalation of bromine at 600 parts per million for 30 minutes by pregnant mice on the 15th day of embryonic development results in significantly lower survival after 96 hours than an identical level of exposure in nonpregnant mice. On the 19th embryonic day, bromine-exposed pregnant mice have increased systemic blood pressure, abnormal placental development, severe fetal growth restriction, systemic inflammation, increased levels of circulating antiangiogenic short fms-like tyrosine kinase-1, and evidence of pulmonary and cardiac injury. Treatment with tadalafil, an inhibitor of type 5 phosphodiesterase, by oral gavage 1 hour post-exposure and then once daily thereafter, attenuated systemic blood pressures, decreased inflammation, ameliorated pulmonary and cardiac injury, and improved maternal survival (from 36% to 80%) and fetal growth. These pathological changes resemble those seen in preeclampsia. Nonpregnant mice did not exhibit any of these pathological changes and were not affected by tadalafil. These findings suggest that pregnant women exposed to bromine may require particular attention and monitoring for signs of preeclampsia-like symptoms.
Indexed as
BromineHypertensionLung InjuryPre-EclampsiaSystemic Inflammatory Response SyndromeAnimalsDisease Models, AnimalFemaleFetal Growth RetardationInhalation ExposureMiceOxidantsPhosphodiesterase 5 InhibitorsPlacentaPregnancyTadalafilBromineOxidantsPhosphodiesterase 5 InhibitorsTadalafilblood pressureheart failurehemodynamicspreeclampsiapregnancy
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