Evidence map›Paper›PMID 28607103›Full record

ArticleCirculation research2017

Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.

Maximillian A Rogers, Natalia Maldonado, Joshua D Hutcheson, Claudia Goettsch, Shinji Goto, Iwao Yamada, Tyler Faits, Hiromi Sesaki, Masanori Aikawa, Elena Aikawa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 117 citations in OpenAlex.

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  17. Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
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  20. [Ketone Body Metabolism and Renal Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023
    Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Maximillian A RogersFrom the Center for Interdisciplinary Cardiovascular Sciences (M.A.R., N.M., J.D.H., C.G., S.G., I.Y., T.F., M.A., E.A.) and Center for Excellence in Vascular Biology (M.A., E.A.), Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD (H.S.).
Natalia MaldonadoFrom the Center for Interdisciplinary Cardiovascular Sciences (M.A.R., N.M., J.D.H., C.G., S.G., I.Y., T.F., M.A., E.A.) and Center for Excellence in Vascular Biology (M.A., E.A.), Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD (H.S.).
Joshua D HutchesonFrom the Center for Interdisciplinary Cardiovascular Sciences (M.A.R., N.M., J.D.H., C.G., S.G., I.Y., T.F., M.A., E.A.) and Center for Excellence in Vascular Biology (M.A., E.A.), Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD (H.S.).
Claudia GoettschFrom the Center for Interdisciplinary Cardiovascular Sciences (M.A.R., N.M., J.D.H., C.G., S.G., I.Y., T.F., M.A., E.A.) and Center for Excellence in Vascular Biology (M.A., E.A.), Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD (H.S.).
Shinji GotoFrom the Center for Interdisciplinary Cardiovascular Sciences (M.A.R., N.M., J.D.H., C.G., S.G., I.Y., T.F., M.A., E.A.) and Center for Excellence in Vascular Biology (M.A., E.A.), Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD (H.S.).
Iwao YamadaFrom the Center for Interdisciplinary Cardiovascular Sciences (M.A.R., N.M., J.D.H., C.G., S.G., I.Y., T.F., M.A., E.A.) and Center for Excellence in Vascular Biology (M.A., E.A.), Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD (H.S.).
Tyler FaitsFrom the Center for Interdisciplinary Cardiovascular Sciences (M.A.R., N.M., J.D.H., C.G., S.G., I.Y., T.F., M.A., E.A.) and Center for Excellence in Vascular Biology (M.A., E.A.), Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD (H.S.).
Hiromi SesakiFrom the Center for Interdisciplinary Cardiovascular Sciences (M.A.R., N.M., J.D.H., C.G., S.G., I.Y., T.F., M.A., E.A.) and Center for Excellence in Vascular Biology (M.A., E.A.), Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD (H.S.).
Masanori AikawaFrom the Center for Interdisciplinary Cardiovascular Sciences (M.A.R., N.M., J.D.H., C.G., S.G., I.Y., T.F., M.A., E.A.) and Center for Excellence in Vascular Biology (M.A., E.A.), Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD (H.S.).
Elena AikawaFrom the Center for Interdisciplinary Cardiovascular Sciences (M.A.R., N.M., J.D.H., C.G., S.G., I.Y., T.F., M.A., E.A.) and Center for Excellence in Vascular Biology (M.A., E.A.), Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD (H.S.). eaikawa@bwh.harvard.edu.
Johns Hopkins University · US

Funding

Macrophage-derived microcalcificaitonsR01HL136431 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI AIKAWA, ELENA · 2017 to 2020
$2.7M
Aortic valve microcalcificationR01HL114805 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI AIKAWA, ELENA · 2012 to 2016
$2.1M
NHLBI NIH HHS R01 HL114805NHLBI NIH HHS R01 HL136431
6 · The paper itself

Abstract

rationaleMitochondrial changes occur during cell differentiation and cardiovascular disease. DRP1 (dynamin-related protein 1) is a key regulator of mitochondrial fission. We hypothesized that DRP1 plays a role in cardiovascular calcification, a process involving cell differentiation and a major clinical problem with high unmet needs.

objectiveTo examine the effects of osteogenic promoting conditions on DRP1 and whether DRP1 inhibition alters the development of cardiovascular calcification. METHODS AND

resultsDRP1 was enriched in calcified regions of human carotid arteries, examined by immunohistochemistry. Osteogenic differentiation of primary human vascular smooth muscle cells increased

conclusionsWe demonstrate a new function of DRP1 in regulating collagen secretion and cardiovascular calcification, a novel area of exploration for the potential development of new therapies to modify cellular fibrocalcific response in cardiovascular diseases. Our data also support a role of mitochondrial dynamics in regulating oxidative stress-mediated arterial calcium accrual and bone loss.

Indexed as

AnimalsCarotid Artery DiseasesCells, CulturedCollagenDynaminsGTP PhosphohydrolasesHumansMaleMiceMice, 129 StrainMice, Inbred C57BLMice, TransgenicMicrotubule-Associated ProteinsMitochondrial ProteinsMyocytes, Smooth MuscleOxidative StressCollagenDNM1L protein, humanDynaminsGTP PhosphohydrolasesMicrotubule-Associated ProteinsMitochondrial ProteinsRNA, Small Interferingatherosclerosiscollagenmitochondriamyocytes, smooth muscleoxidative stress

Identifiers

PMID28607103
PMCPMC5546003
OpenAlexW2625460619

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.