Evidence map›Paper›PMID 28607072›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Adaptor protein mediates dynamic pump assembly for bacterial metal efflux.

Ace George Santiago, Tai-Yen Chen, Lauren A Genova, Won Jung, Alayna M George Thompson, Megan M McEvoy, Peng Chen

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  8. Article
  9. Article
  10. Structural and functional mapping ofComputational and structural biotechnology journal · 2023
    Article
  11. Article
  12. Combined Transcriptomic and Proteomic Profiling ofInternational journal of molecular sciences · 2022
    Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Metal-induced sensor mobilization turns on affinity to activate regulator for metal detoxification in live bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ace George SantiagoDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Tai-Yen ChenDepartment of Chemistry, University of Houston, Houston, TX 77204.
Lauren A GenovaDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Won JungDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Alayna M George ThompsonDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721.
Megan M McEvoyDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095.
Peng ChenDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853; pc252@cornell.edu.ORCID 0000-0001-8582-7661
Cornell University · USUniversity of Arizona · USUniversity of California, Los Angeles · USUniversity of Houston · US

Funding

CHEMISTRY OF BIOLOGICAL SYSTEMST32GM008500 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIN, HENING · 1996 to 2020
$5.4M
Unusual mechanisms of metal regulation in bacteria: from single molecules to single cells to cell communitiesR01GM109993 · NIGMS · CORNELL UNIVERSITY · PI Peng Chen · 2014 to 2026
$3.9M
The Role of Protein Interactions in Microbial Copper/Silver ResistanceR01GM079192 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCEVOY, MEGAN M · 2007 to 2016
$2.4M
Single Molecule Optically Resonant NanoTweezers for the study of Intracellular MeR01GM106420 · NIGMS · CORNELL UNIVERSITY · PI ERICKSON, DAVID CARL · 2013 to 2016
$1.1M
Broad wavelength range Zeiss 780 NLO/confocal system for the Cornell Imaging CoreS10OD018516 · OD · CORNELL UNIVERSITY · PI ZIPFEL, WARREN R · 2014 to 2014
$834k
Single-molecule Imaging of Tripartite Membrane Efflux Pumps in Live BacteriaR21AI117295 · NIAID · CORNELL UNIVERSITY · PI CHEN, PENG · 2015 to 2016
$440k
NIAID NIH HHS R21 AI117295NIGMS NIH HHS R01 GM079192NIGMS NIH HHS R01 GM106420NIGMS NIH HHS R01 GM109993NIGMS NIH HHS T32 GM008500NIH HHS S10 OD018516
6 · The paper itself

Abstract

Multicomponent efflux complexes constitute a primary mechanism for Gram-negative bacteria to expel toxic molecules for survival. As these complexes traverse the periplasm and link inner and outer membranes, it remains unclear how they operate efficiently without compromising periplasmic plasticity. Combining single-molecule superresolution imaging and genetic engineering, we study in living

Indexed as

CopperEscherichia coliEscherichia coli ProteinsIon TransportMembrane ProteinsMembrane Transport ProteinsPeriplasmSilverCopperCusA protein, E coliCusB protein, E coliCusC protein, E coliEscherichia coli ProteinsMembrane ProteinsMembrane Transport ProteinsSilvermetal sensingmulticomponent efflux complexperiplasmic adaptor proteinsingle-molecule trackingsubstrate-responsive dynamic assembly

Identifiers

PMID28607072
PMCPMC5495265
OpenAlexW2626624015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.