Trial reportProceedings of the National Academy of Sciences of the United States of America2017
Brain circuit-gene expression relationships and neuroplasticity of multisensory cortices in blind children.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Excitatory and inhibitory networks diverge following early blindness.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Cortical functional connectivity in mouse models of early blindness: enucleation vs. anophthalmia.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Longitudinal stability of individual brain plasticity patterns in blindness.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A late-life neurogenetic signature of exposure to combat stress - A monozygotic discordant twin study.Journal of psychiatric research · 2024Article
- Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer's disease.Cell reports · 2024Article
- Brain spatial reconciliation through multisensory integration in the impact of pandemic fatigue on workplace.Frontiers in human neuroscience · 2024Article
- Reorganization of integration and segregation networks in brain-based visual impairment.NeuroImage. Clinical · 2024Article
- Longitudinal stability of individual brain plasticity patterns in blindness.bioRxiv : the preprint server for biology · 2023Article
- In search of environmental risk factors for obsessive-compulsive disorder: study protocol for the OCDTWIN project.BMC psychiatry · 2023Article
- In search of environmental risk factors for obsessive-compulsive disorder: Study protocol for the OCDTWIN project.Research square · 2023Article
- Cortical anatomical variations, gene expression profiles, and clinical phenotypes in patients with schizophrenia.NeuroImage. Clinical · 2023Article
- The Role of Visual Experience in Individual Differences of Brain Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Connectomic-genetic signatures in the cerebral small vessel disease.Neurobiology of disease · 2022Article
- Topologic Reorganization of White Matter Connectivity Networks in Early-Blind Adolescents.Neural plasticity · 2022Article
- Neurogenetic traits outline vulnerability to cortical disruption in Parkinson's disease.NeuroImage. Clinical · 2022Article
- Divergent connectomic organization delineates genetic evolutionary traits in the human brain.Scientific reports · 2021Article
- Early-life trauma endophenotypes and brain circuit-gene expression relationships in functional neurological (conversion) disorder.Molecular psychiatry · 2021Article
- Creative Connections: Computational Semantic Distance Captures Individual Creativity and Resting-State Functional Connectivity.Journal of cognitive neuroscience · 2021Article
- Neuroanatomical anomalies associated with rareBrain communications · 2021Article
- Linking Lysosomal Enzyme Targeting Genes and Energy Metabolism with Altered Gray Matter Volume in Children with Persistent Stuttering.Neurobiology of language (Cambridge, Mass.) · 2020Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
Abstract
Sensory deprivation reorganizes neurocircuits in the human brain. The biological basis of such neuroplastic adaptations remains elusive. In this study, we applied two complementary graph theory-based functional connectivity analyses, one to evaluate whole-brain functional connectivity relationships and the second to specifically delineate distributed network connectivity profiles downstream of primary sensory cortices, to investigate neural reorganization in blind children compared with sighted controls. We also examined the relationship between connectivity changes and neuroplasticity-related gene expression profiles in the cerebral cortex. We observed that multisensory integration areas exhibited enhanced functional connectivity in blind children and that this reorganization was spatially associated with the transcription levels of specific members of the cAMP Response Element Binding protein gene family. Using systems-level analyses, this study advances our understanding of human neuroplasticity and its genetic underpinnings following sensory deprivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.