Evidence map›Paper›PMID 28607050›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Mouse model of hematogenous implant-related

Yu Wang, Lily I Cheng, David R Helfer, Alyssa G Ashbaugh, Robert J Miller, Alexander J Tzomides, John M Thompson, Roger V Ortines, Andrew S Tsai, Haiyun Liu and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 78 citations in OpenAlex.

  1. Imaging ofbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Scaffold vaccination for prevention of orthopedic device infection.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
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  14. A novel rodent model of chronic spinal implant-associated infection.The spine journal : official journal of the North American Spine Society · 2023
    Article
  15. Article
  16. Breakdown of clonal cooperative architecture in multispecies biofilms and the spatial ecology of predation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Review
  19. Article
  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Yu WangDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Lily I ChengDepartment of Translational Science, Medimmune, LLC, Gaithersburg, MD 20878.
David R HelferDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Alyssa G AshbaughDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Robert J MillerDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Alexander J TzomidesDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
John M ThompsonDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Roger V OrtinesDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Andrew S TsaiDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Haiyun LiuDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Carly A DillenDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Nathan K ArcherDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Taylor S CohenDepartment of Infectious Disease, Medimmune, LLC, Gaithersburg, MD 20878.
Christine TkaczykDepartment of Infectious Disease, Medimmune, LLC, Gaithersburg, MD 20878.
C Kendall StoverDepartment of Infectious Disease, Medimmune, LLC, Gaithersburg, MD 20878.ORCID 0000-0002-7406-1696
Bret R SellmanDepartment of Infectious Disease, Medimmune, LLC, Gaithersburg, MD 20878.
Lloyd S MillerDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231; lloydmiller@jhmi.edu.
Johns Hopkins University · US

Funding

Training In Orthopaedic Team ScienceT32AR067708 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI JONES, LYNNE C., SHAFIQ, BABAR · 2015 to 2024
$2.0M
NIAMS NIH HHS T32 AR067708
6 · The paper itself

Abstract

Infection is a major complication of implantable medical devices, which provide a scaffold for biofilm formation, thereby reducing susceptibility to antibiotics and complicating treatment. Hematogenous implant-related infections following bacteremia are particularly problematic because they can occur at any time in a previously stable implant. Herein, we developed a model of hematogenous infection in which an orthopedic titanium implant was surgically placed in the legs of mice followed 3 wk later by an i.v. exposure to

Indexed as

Arthritis, InfectiousOsteomyelitisStaphylococcal InfectionsAnimalsAntibodies, BacterialAntibodies, NeutralizingBiofilmsDisease Models, AnimalHumansImplants, ExperimentalMaleMiceStaphylococcus aureusTitaniumAntibodies, BacterialAntibodies, NeutralizingTitaniumbiofilmhematogenousimplantorthopedicStaphylococcus aureus

Identifiers

PMID28607050
PMCPMC5495257
OpenAlexW2624729797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.