Evidence map›Paper›PMID 28606933›Full record

ArticleMolecular and cellular biology2017

Multitiered and Cooperative Surveillance of Mitochondrial Phosphatidylserine Decarboxylase 1.

Oluwaseun B Ogunbona, Ouma Onguka, Elizabeth Calzada, Steven M Claypool

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  10. Article
  11. Article
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  13. Article
  14. Proteolytic Control of Lipid Metabolism.ACS chemical biology · 2019
    Review
  15. Article
  16. Life science alliance · 2019
    Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Oluwaseun B OgunbonaDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID http://orcid.org/0000-0001-5116-7204
Ouma OngukaDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Elizabeth CalzadaDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Steven M ClaypoolDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA sclaypo1@jhmi.edu.ORCID http://orcid.org/0000-0001-5316-1623
Johns Hopkins University · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Mitochondrial phosphatidylethanolamine metabolismR01GM111548 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CLAYPOOL, STEVEN MICHAEL · 2014 to 2021
$2.8M
NIGMS NIH HHS R01 GM111548NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

Phosphatidylserine decarboxylase 1 (Psd1p), an ancient enzyme that converts phosphatidylserine to phosphatidylethanolamine in the inner mitochondrial membrane, must undergo an autocatalytic self-processing event to gain activity. Autocatalysis severs the protein into a large membrane-anchored β subunit that noncovalently associates with the small α subunit on the intermembrane space side of the inner membrane. Here, we determined that a temperature sensitive (

Indexed as

Carboxy-LyasesMitochondriaMitochondrial MembranesMitochondrial ProteinsPhosphatidylethanolaminesPhosphatidylserinesSaccharomyces cerevisiaeCarboxy-LyasesMitochondrial ProteinsphosphatidylethanolaminePhosphatidylethanolaminesphosphatidylserine decarboxylasePhosphatidylserinesmembrane biogenesismembranesphosphatidylethanolaminephospholipidsquality control proteases

Identifiers

PMID28606933
PMCPMC5559681
OpenAlexW2626632307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.