Evidence map›Paper›PMID 28606925›Full record

ArticleThe Journal of cell biology2017

Polarity of varicosity initiation in central neuron mechanosensation.

Yuanzheng Gu, Peter Jukkola, Qian Wang, Thomas Esparza, Yi Zhao, David Brody, Chen Gu

Open access · bronzeAbstract readVideo-Audio Media
In one paragraph

Article in The Journal of cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 66 citations in OpenAlex.

  1. Proper localization of the SCA13-linked KNeurobiology of disease · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Handling Difficult Cryo-ET Samples: A Study with Primary Neurons from Drosophila melanogaster.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2023
    Article
  8. Article
  9. The role of mechanics in axonal stability and development.Seminars in cell & developmental biology · 2023
    Review
  10. Article
  11. Review
  12. Article
  13. Unraveling axonal mechanisms of traumatic brain injury.Acta neuropathologica communications · 2022
    Article
  14. Article
  15. TRPV4: A trigger of pathological RhoA activation in neurological disease.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022
    Article
  16. Article
  17. Article
  18. Review
  19. Mitochondrial behavior when things go wrong in the axon.Frontiers in cellular neuroscience · 2022
    Review
  20. Axonal spheroids in neurodegeneration.Molecular and cellular neurosciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yuanzheng GuDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH.
Peter JukkolaBiomedical Sciences Graduate Program, The Ohio State University, Columbus, OH.ORCID 0000-0001-6076-1117
Qian WangBiomedical Engineering Department, The Ohio State University, Columbus, OH.ORCID 0000-0002-9706-2421
Thomas EsparzaDepartment of Neurology, Washington University, St. Louis, MO.
Yi ZhaoBiomedical Engineering Department, The Ohio State University, Columbus, OH.
David BrodyDepartment of Neurology, Washington University, St. Louis, MO.
Chen GuDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH gu.49@osu.edu.ORCID 0000-0003-3052-4545
The Ohio State University · USWashington University in St. Louis · US

Funding

Polarized Initiation of Varicosity Formation in Central Neuron MechanosensationR01NS093073 · NINDS · OHIO STATE UNIVERSITY · PI GU, CHEN · 2016 to 2025
$3.3M
Mechanism and function of Kv channel targetingR01NS062720 · NINDS · OHIO STATE UNIVERSITY · PI GU, CHEN · 2009 to 2013
$1.4M
Regulation of gray matter myelination by adolescent binge ethanol treatmentR21AA024873 · NIAAA · OHIO STATE UNIVERSITY · PI GU, CHEN · 2017 to 2018
$406k
NIAAA NIH HHS R21 AA024873NINDS NIH HHS R01 NS062720NINDS NIH HHS R01 NS093073
6 · The paper itself

Abstract

Little is known about mechanical regulation of morphological and functional polarity of central neurons. In this study, we report that mechanical stress specifically induces varicosities in the axons but not the dendrites of central neurons by activating TRPV4, a Ca

Indexed as

Cell PolarityMechanotransduction, CellularAction PotentialsAnimalsAxonsBrain Injuries, TraumaticCalcium SignalingDendritesDisease Models, AnimalHEK293 CellsHippocampusHumansMaleMice, Inbred C57BLMice, TransgenicMicrotubulesReceptors, GlutamateTRPV4 protein, humanTrpv4 protein, mouseTrpv4 protein, ratTRPV Cation Channels

Identifiers

PMID28606925
PMCPMC5496611
OpenAlexW2626915014

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.