ArticleNeuroImage2017
Decision ambiguity is mediated by a late positive potential originating from cingulate cortex.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
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- Neural investigation of default effects on decision-making under uncertainty.Scientific reports · 2026Article
- Age-Related Increase in Locus Ceruleus Activity and Connectivity with the Prefrontal Cortex during Ambiguity Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans.Cell reports · 2025Article
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- Graded decisions in the human brain.Nature communications · 2024Article
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- Multimodal investigations of emotional face processing and social trait judgment of faces.Annals of the New York Academy of Sciences · 2024Review
- Debates on the dorsomedial prefrontal/dorsal anterior cingulate cortex: insights for future research.Brain : a journal of neurology · 2023Review
- A uniform human multimodal dataset for emotion perception and judgment.Scientific data · 2023Article
- Functional connectivity between the amygdala and prefrontal cortex underlies processing of emotion ambiguity.Translational psychiatry · 2023Article
- A revisit of the amygdala theory of autism: Twenty years after.Neuropsychologia · 2023Review
- Reduced Pupil Oscillation During Facial Emotion Judgment in People with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2023Article
- Electrophysiological Markers of Fairness and Selfishness Revealed by a Combination of Dictator and Ultimatum Games.Frontiers in systems neuroscience · 2022Article
- Effects of illuminance and correlated color temperature of indoor light on emotion perception.Scientific reports · 2021Article
- Context-based interpersonal relationship modulates social comparison between outcomes: an event-related potential study.Social cognitive and affective neuroscience · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
People often make decisions in the face of ambiguous information, but it remains unclear how ambiguity is represented in the brain. We used three types of ambiguous stimuli and combined EEG and fMRI to examine the neural representation of perceptual decisions under ambiguity. We identified a late positive potential, the LPP, which differentiated levels of ambiguity, and which was specifically associated with behavioral judgments about choices that were ambiguous, rather than passive perception of ambiguous stimuli. Mediation analyses together with two further control experiments confirmed that the LPP was generated only when decisions are made (not during mere perception of ambiguous stimuli), and only when those decisions involved choices on a dimension that is ambiguous. A further control experiment showed that a stronger LPP arose in the presence of ambiguous stimuli compared to when only unambiguous stimuli were present. Source modeling suggested that the LPP originated from multiple loci in cingulate cortex, a finding we further confirmed using fMRI and fMRI-guided ERP source prediction. Taken together, our findings argue for a role of an LPP originating from cingulate cortex in encoding decisions based on task-relevant perceptual ambiguity, a process that may in turn influence confidence judgment, response conflict, and error correction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.