Trial reportAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2017
Cognitive Function and Kidney Disease: Baseline Data From the Systolic Blood Pressure Intervention Trial (SPRINT).
Trial report in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 78 citations in OpenAlex.
- Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Trial
- Kidney Disease, Intensive Hypertension Treatment, and Risk for Dementia and Mild Cognitive Impairment: The Systolic Blood Pressure Intervention Trial.Journal of the American Society of Nephrology : JASN · 2020Trial
- Influence of baseline systolic blood pressure on the relationship between intensive blood pressure control and cardiovascular outcomes in the Systolic Blood Pressure Intervention Trial (SPRINT).Clinical research in cardiology : official journal of the German Cardiac Society · 2019Trial
- Mortality trends for chronic kidney disease and dementia in the United States, 1999-2020: a 22-year retrospective analysis.Annals of medicine and surgery (2012) · 2026Article
- Article
- Associations Between Renal Function, Uremic Toxins, and Cognitive Performance in Patients with Chronic Kidney Disease: A Pilot Study.International journal of medical sciences · 2026Observational
- Health octo tool matches personalized health with rate of aging.Nature communications · 2025Article
- The impact of chronic kidney disease on prognosis in acute stroke: unraveling the pathophysiology and clinical complexity for optimal management.Clinical and experimental nephrology · 2025Review
- Relationships of hematocrit concentration with dementia from a multiethnic population-based study.Frontiers in aging neuroscience · 2025Article
- Impaired kidney function, cerebral small vessel disease and cognitive disorders: the Framingham Heart Study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- Cognitive profile of kidney transplant patients and impact of deceased vs. living donor transplantation.Journal of nephrology · 2024Article
- Incident dementia in kidney transplantation recipients: a matched comparative nationwide cohort study in South Korea.Kidney research and clinical practice · 2023Article
- CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia.Kidney medicine · 2023Article
- Association of Kidney Function Measures With Signs of Neurodegeneration and Small Vessel Disease on Brain Magnetic Resonance Imaging: The Atherosclerosis Risk in Communities (ARIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023Article
- The estimated glomerular filtration rate was U-shaped associated with abdominal aortic calcification in US adults: findings from NHANES 2013-2014.Frontiers in cardiovascular medicine · 2023Article
- Association between kidney measurements and cognitive performance in patients with ischemic stroke.PloS one · 2023Article
- The association between dietary inflammatory index and cognitive function in adults with/without chronic kidney disease.Frontiers in nutrition · 2023Article
- Article
- Cognitive Sequelae and Hippocampal Dysfunction in Chronic Kidney Disease following 5/6 Nephrectomy.Brain sciences · 2022Article
- Reduced kidney function is associated with poorer domain-specific cognitive performance in community-dwelling older adults.International journal of geriatric psychiatry · 2022Article
Corrections and comments
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Authors and funding
18 authors at 14 institutions in 1 country.
Funding
Abstract
backgroundChronic kidney disease is common and is associated with cardiovascular disease, cerebrovascular disease, and cognitive function, although the nature of this relationship remains uncertain. STUDY
designCross-sectional cohort using baseline data from the Systolic Blood Pressure Intervention Trial (SPRINT). SETTING &
participantsParticipants in SPRINT, a randomized clinical trial of blood pressure targets in older community-dwelling adults with cardiovascular disease, chronic kidney disease, or high cardiovascular disease risk and without diabetes or known stroke, who underwent detailed neurocognitive testing in the cognition substudy, SPRINT-Memory and Cognition in Decreased Hypertension (SPRINT-MIND). PREDICTORS: Urine albumin-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR). OUTCOMES: Cognitive function, a priori defined as 5 cognitive domains based on 11 cognitive tests using z scores, and abnormal white matter volume quantified by brain magnetic resonance imaging.
resultsOf 9,361 SPRINT participants, 2,800 participated in SPRINT-MIND and 2,707 had complete data; 637 had brain imaging. Mean age was 68 years, 37% were women, 30% were black, and 20% had known cardiovascular disease. Mean eGFR was 70.8±20.9mL/min/1.73m LIMITATIONS: Cross-sectional only, no patients with diabetes were included.
conclusionsIn older adults, higher urine ACR and lower eGFR have independent associations with global cognitive performance with different affected domains. Albuminuria concurrently identifies a higher burden of abnormal brain white matter disease, suggesting that vascular disease may mediate these relationships.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.