Evidence map›Paper›PMID 28606360›Full record

ArticleCellular immunology2017

Sex differences in regulatory cells in experimental stroke.

Hilary A Seifert, Gil Benedek, Jian Liang, Ha Nguyen, Gail Kent, Arthur A Vandenbark, Julie A Saugstad, Halina Offner

Open access · greenAbstract read
In one paragraph

Article in Cellular immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Inflammatory Responses After Ischemic Stroke.Seminars in immunopathology · 2022
    Review
  13. Article
  14. Article
  15. Review
  16. Hydroxysafflor Yellow A Blocks HIF-1Antioxidants (Basel, Switzerland) · 2022
    Article
  17. ERK1/2 Activity Is Critical for the Outcome of Ischemic Stroke.International journal of molecular sciences · 2022
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hilary A SeifertNeuroimmunology Research, VA Portland Health Care System, Portland, OR, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
Gil BenedekNeuroimmunology Research, VA Portland Health Care System, Portland, OR, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
Jian LiangDepartment of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA.
Ha NguyenNeuroimmunology Research, VA Portland Health Care System, Portland, OR, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
Gail KentNeuroimmunology Research, VA Portland Health Care System, Portland, OR, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
Arthur A VandenbarkNeuroimmunology Research, VA Portland Health Care System, Portland, OR, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, USA; Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, USA.
Julie A SaugstadDepartment of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA.
Halina OffnerNeuroimmunology Research, VA Portland Health Care System, Portland, OR, USA; Department of Neurology, Oregon Health & Science University, Portland, OR, USA; Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA. Electronic address: offnerva@ohsu.edu.
Oregon Health & Science University · USVA Portland Health Care System · US

Funding

Sex differences in brain inflammation in experimental strokeR01NS076013 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI OFFNER, HALINA, SAUGSTAD, JULIE ANNE · 2012 to 2016
$2.3M
Regulatory B-cells Limit CNS Inflammation and Infarct in Experimental StrokeR01NS075887 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI OFFNER, HALINA · 2011 to 2015
$1.8M
A Novel Intervention Strategy for Stroke with RTL TherapyR42NS065515 · NINDS · VIROGENOMICS, INC. · PI ALKAYED, NABIL J, OFFNER, HALINA · 2012 to 2013
$1.4M
NINDS NIH HHS R01 NS075887NINDS NIH HHS R01 NS076013
6 · The paper itself

Abstract

Stroke is the leading cause of disability in the United States. Sex differences, including smaller infarcts in females and greater involvement of immune-mediated inflammation in males may affect the efficacy of immune-modulating interventions. To address these differences, we sought to identify distinct stroke-modifying mechanisms in female vs. male mice. The current study demonstrated smaller infarcts and increased levels of regulatory CD19

Indexed as

SexAnimalsB-Lymphocytes, RegulatoryBrainCells, CulturedDisease Models, AnimalFemaleHumansMacrophagesMaleMiceMice, Inbred C57BLMiddle Cerebral ArterySex FactorsStrokeAnti-inflammatory macrophagesLymphocyteMiddle cerebral artery occlusionRegulatory B cellsRegulatory T cellsSex-specific

Identifiers

PMID28606360
PMCPMC5551457
OpenAlexW2621513897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.