Evidence map›Paper›PMID 28606304›Full record

ArticleeLife2017

Presynaptic LRP4 promotes synapse number and function of excitatory CNS neurons.

Timothy J Mosca, David J Luginbuhl, Irving E Wang, Liqun Luo

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 67 citations in OpenAlex.

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  16. Synaptic Development in Diverse Olfactory Neuron Classes Uses Distinct Temporal and Activity-Related Programs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Timothy J MoscaDepartment of Neuroscience, Thomas Jefferson University, Philadelphia, United States.ORCID 0000-0003-3485-0719
David J LuginbuhlDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, United States.
Irving E WangDepartment of Neurobiology, Stanford University, Stanford, United States.
Liqun LuoDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, United States.ORCID 0000-0001-5467-9264
Howard Hughes Medical Institute · USStanford University · US

Funding

Assembly of the Central Olfactory Networks in DrosophilaR01DC005982 · NIDCD · STANFORD UNIVERSITY · PI LIQUN LUO · 2003 to 2026
$8.1M
The Development and Organization of Central Synapses in DrosophilaR00DC013059 · NIDCD · THOMAS JEFFERSON UNIVERSITY · PI MOSCA, TIMOTHY J. · 2017 to 2019
$741k
The Development and Organization of Central Synapses in DrosophilaK99DC013059 · NIDCD · STANFORD UNIVERSITY · PI MOSCA, TIMOTHY J. · 2013 to 2014
$180k
NIDCD NIH HHS K99 DC013059NIDCD NIH HHS R00 DC013059NIDCD NIH HHS R01 DC005982
6 · The paper itself

Abstract

Precise coordination of synaptic connections ensures proper information flow within circuits. The activity of presynaptic organizing molecules signaling to downstream pathways is essential for such coordination, though such entities remain incompletely known. We show that LRP4, a conserved transmembrane protein known for its postsynaptic roles, functions presynaptically as an organizing molecule. In the

Indexed as

Neuronal PlasticityAnimalsBrainDrosophilaGene ExpressionGene Knockout TechniquesLDL-Receptor Related ProteinsNeuronsPresynaptic TerminalsReceptors, PresynapticLDL-Receptor Related ProteinsReceptors, PresynapticD. melanogasterlrp4neuroscienceolfactorypresynapticreceptorssynapse

Identifiers

PMID28606304
PMCPMC5469616
OpenAlexW2949501662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.