Evidence map›Paper›PMID 28606245›Full record

ArticleJournal of psychiatry & neuroscience : JPN2017

Prefrontal brain responsiveness to negative stimuli distinguishes familial risk for major depression from acute disorder.

Nils Opel, Ronny Redlich, Dominik Grotegerd, Katharina Dohm, Dario Zaremba, Susanne Meinert, Christian Bürger, Leonie Plümpe, Judith Alferink, Walter Heindel and 4 more

Abstract read
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In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Molecular, Structural, and Functional Neuroimaging in Major Depression.Advances in experimental medicine and biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Prefrontal cortex and depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Review
  9. Article
  10. Task MRI-Based Functional Brain Network of Major Depression.Advances in experimental medicine and biology · 2021
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nils OpelFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).
Ronny RedlichFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).
Dominik GrotegerdFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).
Katharina DohmFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).
Dario ZarembaFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).
Susanne MeinertFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).
Christian BürgerFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).
Leonie PlümpeFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).
Judith AlferinkFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).
Walter HeindelFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).
Harald KugelFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).
Peter ZwanzgerFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).
Volker AroltFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).
Udo DannlowskiFrom the Department of Psychiatry, University of Münster, Münster, Germany (Opel, Redlich, Grotegerd, Dohm, Zaremba, Meinert, Bürger, Plümpe, Alferink, Arolt, Dannlowski); the Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany (Alferink); the Department of Clinical Radiology, University of Münster, Münster, Germany (Heindel, Kugel); the kbo-Inn-Salzach-Klinikum, Wasserburg am Inn, Germany (Zwanzger); the Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany (Zwanzger); and the Department of Psychiatry, University of Marburg, Marburg, Germany (Dannlowski).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdentifying reliable trait markers of familial risk for major depressive disorder (MDD) is a challenge in translational psychiatric research. In individuals with acute MDD, dysfunctional connectivity patterns of prefrontal areas have been shown repeatedly. However, it has been unclear in which neuronal networks functional alterations in individuals at familial risk for MDD might be present and to what extent they resemble findings previously reported in those with acute MDD.

methodsWe investigated differences in blood oxygen level-dependent (BOLD) response of the medial orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC) to aversive stimuli between acute MDD and familial risk for the disorder in healthy first-degree relatives of acutely depressed patients with MDD (HC-FH+), healthy age- and sex-matched controls without any family history of depression (HC-FH-), and acutely depressed patients with MDD with (MDD-FH+) and without a family history of depression (MDD-FH-) during a frequently used emotional face-matching paradigm. Analyses of task-specific network connectivity were conducted in terms of psychophysiological interactions (PPI).

resultsThe present analysis included a total of 100 participants: 25 HC-FH+, 25 HC-FH-, 25 MDD-FH+ and 25 MDD-FH-. Patients with MDD exhibited significantly increased activation in the medial OFC to negative stimuli irrespective of familial risk status, whereas healthy participants at familial risk and patients with MDD alike showed significant hypoactivation in the DLPFC compared with healthy participants without familial risk. The PPI analyses revealed significantly enhanced task-specific coupling between the medial OFC and differing cortical areas in individuals with acute MDD and those with familial risk for the disorder. LIMITATIONS: The main limitation of our study is its cross-sectional design.

conclusionWhereas hypoactivation during negative emotion processing in the DLPFC appears as a common feature in both healthy high-risk individuals and acutely depressed patients, activation patterns of the medial OFC and its underlying connectivity seem to distinguish familial risk from acute disorder.

Indexed as

FamilyGenetic Predisposition to DiseaseAdultBrain MappingCerebrovascular CirculationCross-Sectional StudiesEmotionsFemaleHumansMagnetic Resonance ImagingMajor Depressive DisorderMaleNeuropsychological TestsOxygenPrefrontal CortexOxygen

Identifiers

PMID28606245
PMCPMC5573576

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