ArticleBMC medicine2017
Recent household transmission of tuberculosis in England, 2010-2012: retrospective national cohort study combining epidemiological and molecular strain typing data.
Article in BMC medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Quantifying within-household tuberculosis transmission: a systematic review and prospective cohort study.International journal of epidemiology · 2026Pooled it
- Global variation in bacterial strains that cause tuberculosis disease: a systematic review and meta-analysis.BMC medicine · 2018Pooled it
- [Molecular Epidemiological Analysis of Tuberculosis Transmission in Households in Republic of Korea, 2016-2024].Jugan geon-gang gwa jilbyeong · 2025Article
- The impact of COVID-19 on tuberculosis in most populated state of India: A geospatial meta-analysis.Journal of family medicine and primary care · 2024Review
- Population-Based Severe Acute Respiratory Syndrome Coronavirus 2 Whole-Genome Sequencing and Contact Tracing During the Coronavirus Disease 2019 Pandemic in Switzerland.The Journal of infectious diseases · 2023Article
- Using phylogenetics to infer HIV-1 transmission direction between known transmission pairs.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- How much do smear-negative patients really contribute to tuberculosis transmissions? Re-examining an old question with new tools.EClinicalMedicine · 2022Article
- Transmission of tuberculosis between foreign-born and Finnish-born populations in Finland, 2014-2017.PloS one · 2021Article
- A Whole-Genome Sequencing-Based Study to Delineate the Risk and Characteristics of Tuberculosis Transmission in an Insular Population Over 10 Years in Shanghai.Frontiers in microbiology · 2021Article
- Impact of the COVID-19 Pandemic on Tuberculosis Control: An Overview.Tropical medicine and infectious disease · 2020Article
- A Framework for Network-Based Epidemiological Modeling of Tuberculosis Dynamics Using Synthetic Datasets.Bulletin of mathematical biology · 2020Article
- A model of tuberculosis clustering in low incidence countries reveals more transmission in the United Kingdom than the Netherlands between 2010 and 2015.PLoS computational biology · 2020Article
- Assessment of the use and need for an integrated molecular surveillance of tuberculosis: an online survey in Germany.BMC public health · 2019Article
- Contacts of underserved tuberculosis patients have higher odds of TB disease in North West England: a cohort study.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2019Article
- Mycobacterium tuberculosis transmission in an ethnically-diverse high incidence region in England, 2007-11.BMC infectious diseases · 2019Article
- Whole genome sequencing for improved understanding of Mycobacterium tuberculosis transmission in a remote circumpolar region.Epidemiology and infection · 2019Article
- Creating a web-based electronic tool to aid tuberculosis (TB) cluster investigation: data integration in TB surveillance activities in the United Kingdom, 2013 to 2016.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018Article
- Delay from symptom onset to treatment start among tuberculosis patients in England, 2012-2015.Epidemiology and infection · 2018Article
- Observational
- Transmission events revealed in tuberculosis contact investigations in London.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe estimate the proportion of tuberculosis (TB) in England due to recent household transmission, identify factors associated with being a household transmitter, and investigate the impact that identification of a case has on time to treatment of subsequent cases.
methodsTB cases notified between 2010 and 2012 in England in the same household as another case were identified; 24 locus MIRU-VNTR strain typing (ST) was used to identify household cases with likely recent transmission. Treatment delay in index and subsequent cases was compared. Risk factors for being a household transmitter were identified in univariable and multivariable analyses.
resultsOverall, 7.7% (1849/24,060) of TB cases lived in a household with another case. We estimate that 3.9% were due to recent household transmission. ST data was unavailable for 67% (1242) of household pairs. For those with ST data, 64% (386) had confirmed, 11% probable (66) and 25% (155) refuted household transmission. The median treatment delay was 65 days for index cases and 37 days for subsequent asymptomatic cases. Risk factors for being a household transmitter included being under 25 years old, UK-born with Black African, Indian or Pakistani ethnicity, or born in Somalia or Romania.
conclusionsThis study has a number of implications for household TB contact tracing in low incidence countries, including the potential to reduce the diagnostic delay for subsequent household cases and the benefit of using ST to identify when to conduct source contact tracing outside the household. As 25% of TB cases in households had discordant strains, households with multiple TB cases do not necessarily represent household transmission. The additional fact that 25% of index cases within households only had extra-pulmonary TB demonstrates that, if household contact tracing is limited to pulmonary TB cases (as recently recommended in UK guidelines), additional cases of active TB in households will be missed. Our finding that no lineage of TB was associated with recent household transmission and with no increased transmissibility in the Beijing lineage compared to others, suggests that the lineage need not impact contact tracing efforts. Improvements in contact tracing have the potential to reduce transmission of TB in low incidence countries.
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