ArticleMicrobial cell factories2017
Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast.
Article in Microbial cell factories, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Genome mining and functional characterization of four type I sesquiterpene synthases from the Tiger Milk Mushroom Lignosus rhinocerus.Natural products and bioprospecting · 2026Article
- Sesquiterpene synthases fromMycology · 2026Article
- Chemical Composition and Biological Activities of the Essential Oils from Different Parts ofMolecules (Basel, Switzerland) · 2025Article
- Characterization of the Cubamyces Menziesii Terpenome.Chembiochem : a European journal of chemical biology · 2025Article
- Haplotype-resolved genomes ofIMA fungus · 2025Article
- Genomic Features ofJournal of fungi (Basel, Switzerland) · 2024Article
- Comparative genomics unravels a rich set of biosynthetic gene clusters with distinct evolutionary trajectories across fungal species (Termitomyces) farmed by termites.Communications biology · 2024Article
- Genome Mining of Fungal Unique Trichodiene Synthase-like Sesquiterpene Synthases.Journal of fungi (Basel, Switzerland) · 2024Article
- Telomere-to-Telomere Genome Assembly of Tibetan Medicinal MushroomJournal of fungi (Basel, Switzerland) · 2023Article
- Molecular and Functional Analyses of Characterized Sesquiterpene Synthases in Mushroom-Forming Fungi.Journal of fungi (Basel, Switzerland) · 2023Article
- Article
- Genomic and Transcriptomic Approaches Provide a Predictive Framework for Sesquiterpenes Biosynthesis inJournal of fungi (Basel, Switzerland) · 2023Article
- Are chemical compounds in medical mushrooms potent against colorectal cancer carcinogenesis and antimicrobial growth?Cancer cell international · 2022Review
- Extraction of a Triterpene Solution and Evaluation of the Hypolipidemic Efficacy of theFoods (Basel, Switzerland) · 2022Article
- Biosynthesis of Sesquiterpenes in Basidiomycetes: A Review.Journal of fungi (Basel, Switzerland) · 2022Review
- Genome Assembly and Genetic Traits of the Pleuromutilin-ProducerJournal of fungi (Basel, Switzerland) · 2022Article
- Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol.Microbial cell factories · 2022Article
- Whole Genome Sequencing and Annotation ofJournal of fungi (Basel, Switzerland) · 2021Article
- Biosynthesis and regulation of terpenoids from basidiomycetes: exploration of new research.AMB Express · 2021Review
- (Molecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenome mining facilitated by heterologous systems is an emerging approach to access the chemical diversity encoded in basidiomycete genomes. In this study, three sesquiterpene synthase genes, GME3634, GME3638, and GME9210, which were highly expressed in the sclerotium of the medicinal mushroom Lignosus rhinocerotis, were cloned and heterologously expressed in a yeast system.
resultsMetabolite profile analysis of the yeast culture extracts by GC-MS showed the production of several sesquiterpene alcohols (C
conclusionsThis demonstrates that yeast-based genome mining, guided by transcriptomics, is a promising approach for uncovering bioactive compounds from medicinal mushrooms.
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