Evidence map›Paper›PMID 28606104›Full record

Observational studyBMC cardiovascular disorders2017

Unlocking echocardiogram measurements for heart disease research through natural language processing.

Olga V Patterson, Matthew S Freiberg, Melissa Skanderson, Samah J Fodeh, Cynthia A Brandt, Scott L DuVall

Abstract readMulticenter StudyObservational StudyValidation Study
In one paragraph

Observational study in BMC cardiovascular disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  11. A Multi-Task Deep Learning Model for Pediatric Echocardiography Analysis.medRxiv : the preprint server for health sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olga V PattersonDepartment of Veterans Affairs Salt Lake City Health Care System, 500 Foothill Drive Bldg. Mail Code 182, Salt Lake City, 84148, UT, USA. olga.patterson@utah.edu.ORCID 0000-0002-8717-5975
Matthew S FreibergVA Tennessee Valley Health Care System, Nashville, TN, USA.
Melissa SkandersonConnecticut VA Healthcare System, West Haven, CT, USA.
Samah J FodehCenter for Medical Informatics, School of Medicine, Yale University, West Haven, CT, USA.
Cynthia A BrandtConnecticut VA Healthcare System, West Haven, CT, USA.
Scott L DuVallDepartment of Veterans Affairs Salt Lake City Health Care System, 500 Foothill Drive Bldg. Mail Code 182, Salt Lake City, 84148, UT, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Cardiovascular Disease Mechanisms in HIV Infected and Uninfected VeteransR01HL095136 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREIBERG, MATTHEW S, JUSTICE, AMY CAROLINE · 2008 to 2012
$5.6M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

backgroundIn order to investigate the mechanisms of cardiovascular disease in HIV infected and uninfected patients, an analysis of echocardiogram reports is required for a large longitudinal multi-center study. IMPLEMENTATION: A natural language processing system using a dictionary lookup, rules, and patterns was developed to extract heart function measurements that are typically recorded in echocardiogram reports as measurement-value pairs. Curated semantic bootstrapping was used to create a custom dictionary that extends existing terminologies based on terms that actually appear in the medical record. A novel disambiguation method based on semantic constraints was created to identify and discard erroneous alternative definitions of the measurement terms. The system was built utilizing a scalable framework, making it available for processing large datasets.

resultsThe system was developed for and validated on notes from three sources: general clinic notes, echocardiogram reports, and radiology reports. The system achieved F-scores of 0.872, 0.844, and 0.877 with precision of 0.936, 0.982, and 0.969 for each dataset respectively averaged across all extracted values. Left ventricular ejection fraction (LVEF) is the most frequently extracted measurement. The precision of extraction of the LVEF measure ranged from 0.968 to 1.0 across different document types.

conclusionsThis system illustrates the feasibility and effectiveness of a large-scale information extraction on clinical data. New clinical questions can be addressed in the domain of heart failure using retrospective clinical data analysis because key heart function measurements can be successfully extracted using natural language processing.

Indexed as

EchocardiographyNatural Language ProcessingSoftware ValidationTerminology as TopicAutomationDatabases, FactualData MiningFeasibility StudiesHeart FailureHIV InfectionsHumansLongitudinal StudiesPattern Recognition, AutomatedPredictive Value of TestsReproducibility of ResultsRetrospective StudiesEchocardiographyHeart functionInformation extractionLeft ventricular ejection fractionNatural language processingText mining

Identifiers

PMID28606104
PMCPMC5469017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.