ArticleLipids in health and disease2017
Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress.
Article in Lipids in health and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Spatial lipid-barrier coupling in knee osteoarthritis: a mechanism-based perspective centered on the infrapatellar fat pad.Therapeutic advances in musculoskeletal disease · 2026Review
- Unraveling the connection between obesity, metabolic syndrome and osteoarthritis risk: a large-observational study.Diabetology & metabolic syndrome · 2025Article
- The role of metabolites in the progression of osteoarthritis: Mechanisms and advances in therapy.Journal of orthopaedic translation · 2025Review
- Obesity and hyperlipidemia were associated with more severe synovitis and structural abnormalities as well as inferior functional outcomes in knee osteoarthritis: a retrospective comparative study.Journal of orthopaedic surgery and research · 2024Article
- Obesity, Metabolic Syndrome, and Osteoarthritis Require Integrative Understanding and Management.Biomedicines · 2024Review
- Novel insights into the role of metabolic disorder in osteoarthritis.Frontiers in endocrinology · 2024Review
- Cross-talk of inflammation and chondrocyte intracellular metabolism in osteoarthritis.Osteoarthritis and cartilage · 2023Review
- Promotion of Joint Degeneration and Chondrocyte Metabolic Dysfunction by Excessive Growth Hormone in Mice.Arthritis & rheumatology (Hoboken, N.J.) · 2023Article
- Macrophage-Driven Inflammation in Metabolic Osteoarthritis: Implications for Biomarker and Therapy Development.International journal of molecular sciences · 2023Review
- Review
- Senescence in osteoarthritis: from mechanism to potential treatment.Arthritis research & therapy · 2022Review
- Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Review
- Osteoblasts impair cholesterol synthesis in chondrocytes via Notch1 signalling.Cell proliferation · 2021Article
- Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes : Secretome of synoviocytes induces chondrocyte damage.Clinical rheumatology · 2021Article
- Fatty Acids and Oxylipins in Osteoarthritis and Rheumatoid Arthritis-a Complex Field with Significant Potential for Future Treatments.Current rheumatology reports · 2021Review
- NLRP3 Inflammasome: The Stormy Link Between Obesity and COVID-19.Frontiers in immunology · 2020Review
- The burden of metabolic syndrome on osteoarthritic joints.Arthritis research & therapy · 2019Review
- Natural Products for Promoting Joint Health and Managing Osteoarthritis.Current rheumatology reports · 2018Review
- Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low-Grade Inflammation in Osteoarthritis.Oxidative medicine and cellular longevity · 2018Review
- Changes in Plasma Metabolites Concentrations in Obese Dogs Supplemented With Anti-oxidant Compound.Frontiers in nutrition · 2018Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, two pathogenic pathways describe the role of obesity in osteoarthritis (OA); one through biomechanical stress, and the other by the contribution of systemic inflammation. The aim of this study was to evaluate the effect of free fatty acids (FFA) in human chondrocytes (HC) expression of proinflammatory factors and reactive oxygen species (ROS).
methodsHC were exposed to two different concentrations of FFA in order to evaluate the secretion of adipokines through cytokines immunoassays panel, quantify the protein secretion of FFA-treated chondrocytes, and fluorescent cytometry assays were performed to evaluate the reactive oxygen species (ROS) production.
resultsHC injury was observed at 48 h of treatment with FFA. In the FFA-treated HC the production of reactive oxygen species such as superoxide radical, hydrogen peroxide
conclusionIn our in vitro model of HC, a hyperlipidemia microenvironment induces an oxidative stress state that enhances the inflammatory process mediated by adipokines secretion in HC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.